1-Cyclohexyl-3-[2-(4-methylmorpholino)ethyl]carbodiimide p-Toluenesulfonate 1-环已基-2-吗啉乙基碳二亚胺对甲苯磺酸盐

CAS 2491-17-0 MFCD00011979

化学结构图

2491-17-0
SMILES: C[N+]1(CCN=C=NC2CCCCC2)CCOCC1.Cc1ccc(S(=O)(=O)[O-])cc1

化学属性

Mol. FormulaC21H33N3O4S
Mol. Weight423.57
Density1.422
Melting Point115-120°C
TSCAYes
Stability易吸潮

别名和识别编码

Chemical Name1-Cyclohexyl-3-[2-(4-methylmorpholino)ethyl]carbodiimide p-Toluenesulfonate
CAS Number2491-17-0
EC Number219-650-3
Beilstein Registry Number3872192
MDL NumberMFCD00011979
Synonym CME-carbodiimide {LY} CME-carbodiimide {} {LY} CME-carbodiimide {} {} {LY} CME-carbodiimide {} {} {} {LY} CME-carbodiimide {} {} {} {} {LY} CME-carbodiimide {} {} {} {} {} {LY} CME-carbodiimide {} {} {} {} {} {} {LY} CME-carbodiimide {} {} {} {} {} {} {} {LY} CME-carbodiimide {} {} {} {} {} {} {} {} {LY} CME-carbodiimide {} {} {} {} {} {} {} {} {} {LY} CME-carbodiimide {} {} {} {} {} {} {} {} {} {} {LY} CME-carbodiimide {} {} {} {} {} {} {} {} {} {} {} {LY} CME-carbodiimide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} CME-carbodiimide {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} CME-carbodiimide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} CME-carbodiimide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} CME-carbodiimide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} CME-carbodiimide
PubChem Substance ID17220
Reaxys-RN3872192
Chemical Name Translation1-环已基-2-吗啉乙基碳二亚胺对甲苯磺酸盐
InChIKeyGBCAVSYHPPARHX-UHFFFAOYSA-M
LabNetwork Molecule IDLN01741032
InChIInChI=1S/C14H26N3O.C7H8O3S/c1-17(9-11-18-12-10-17)8-7-15-13-16-14-5-3-2-4-6-14;1-6-2-4-7(5-3-6)11(8,9)10/h14H,2-12H2,1H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1
Canonical SMILESC[N+]1(CCN=C=NC2CCCCC2)CCOCC1.O=S(C3=CC=C(C)C=C3)([O-])=O
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分类

  • {SNA} Peptide Synthesis, Peptides, 生化试剂
  • {SNA} Building Blocks, C11 to C20+, Chemical Synthesis, Heterocyclic Building Blocks, Morpholines/Thiomorpholines
  • {SNA} Biochemicals and Reagents, Peptide Synthesis, Peptides

产品应用

  • 用于多肽合成，在亲和色谱中用作偶联配体。

相关文献及参考

  • Peptide coupling reagent (see Appendix 6; compare N,N'-Dicyclohexyl­carbodiimide, A10973, and 1-(3-Dimethyl­aminopropyl)-3-ethyl­carbodiimide hydrochloride, A10807) producing a urea by-product which is soluble in dilute acid, and hence easily removable from the reaction mixture: J. Org. Chem., 21, 439 (1956); J. Am. Chem. Soc., 87, 4373 (1965). Has also found use as a superior regent for macrolactonization: J. Am. Chem. Soc., 104. 4708 (1982).
  • Beilstein: 27,IV,393

安全信息

Signal word
GHS Symbol
WGK Germany3
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P332+P313
  • P305+P351+P338+P337+P313
  • P302+P350
  • P337+P313
Storage condition -20°C {LY} -20°C 2-8°C 保存 Moisture Sensitive {} {LY} -20°C {} {} {LY} -20°C {} {} {} {LY} -20°C {} {} {} {} {LY} -20°C {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi

其他信息

  • 溶于水。

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Peptides - Biochemicals and Reagents
  4. Peptide Synthesis 多肽合成
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Peptides - Biochemicals and Reagents
  4. Peptide Synthesis 多肽合成
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Isoxazoles 异恶唑
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Morpholines/Thiomorpholines 吗啉/硫吗啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Morpholines/Thiomorpholines 吗啉/硫吗啉
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Coupling - Synthetic Reagents
  4. Carbodiimides - Coupling
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Condensation & Active Esterification
  1. Functional Group 官能团索引
  2. quaternary ammonium salt
  1. Functional Group 官能团索引
  2. carbodiimide
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Peptide Synthesis
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Peptides
  4. Peptide Analysis and Characterization
  5. Crystallization Reagents

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