Ethyl Biscoumacetate

CAS 548-00-5 MFCD00128073

化学结构图

548-00-5
SMILES: CCOC(=O)C(c1c(O)c2ccccc2oc1=O)c1c(O)c2ccccc2oc1=O

化学属性

Mol. FormulaC22H16O8
Mol. Weight408.38

别名和识别编码

Chemical NameEthyl Biscoumacetate
CAS Number548-00-5
Synonym Neodicumarinum Ethyl bis(4-hydroxy-3-coumarinyl)acetate Bis-(4-hydroxy-3-coumarinyl)ethyl acetate Trombarin ######## Neodicoumarin Neodicoumarol Trombil Bis(4-hydroxy-3-coumarin)acetic acid ethyl ester Pelentan 3,3'-Carbaethoxymethylen-bis-(4-oxy-cumarin) Dicumacyl Neodikumarin Bis-3,3'-(4-hydroxycumarinyl)acetic acid ethyl ester Ethyl biscoumacetate BOEA Ethyl bis(4-hydroxycoumarinyl)acetate Ethyl 4,4'-dihydroxydicoumarinyl-3,3'-acetate Bis(4-hydroxy-2-oxo-2H-1-benzopyran-3-yl)acetic acid ethyl ester Neodicumarol Trombolysan 3,3'-(Carboxymethylene)bis(4-hydroxycoumarin) ethyl ester Tromexan Ethyldicoumarol acetate
Chemical Name Translation
Wiswesser Line NotationT66 BOVJ EQ DYVO2&- DT66 BOVJ EQ
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分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Anticoagulant.

相关文献及参考

  • Gruber, C.M., et al.: Fed. Proc., 10, 303 (1951),
  • 28) Jones, G., et al.: J. Mol. Biol., 267, 727 (1997),
  • Du, J., et al.: J. Biol. Chem., 281, 37416 (2006),

安全信息

RTECSAF5775000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 222,107,1954

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 222,107,1954

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 260 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Cardiac - change in force of contraction
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 87,402,1

TYPE OF TEST            : LD50 - Lethal dose, 50 pe

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 170 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Soci

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 48 mg/kg
SEX/DURATION            : female 36-37 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Effects on Newborn - stillbirth
   Reproductive - Effects on Newborn - other neonatal measures or effects
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   2,719,1955

系列性分类

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