Kallikrein from porcine pancreas Kallikrein

CAS 9001-01-8 MFCD00131428

化学结构图

9001-01-8
SMILES:

别名和识别编码

Synonym Kininogenase 胰激肽释放酶 Padutin Depot-padutin Urinary kallikrein Dilminal D Padreatin Kallidinogenase Callicrein Kininogenin E.C. 3.4.21.8 Kininogen high molecular weight, Two Chain 来源于人类血浆 Kininogen, low molecular weight 来源于人类血浆 Urokallikrein LMW kininogen Kallikrein 来源于人类血浆 Pancreatic kallikrein Glumorin Kininogenase Kininogenin Onokrein P SK-827 E.C. 3.4.4.21 Bradykini
MDL NumberMFCD00131428
CAS Number9001-01-8
EC Number232-574-5
Chemical NameKallikrein from porcine pancreas >=40 units/mg protein
Chemical Name TranslationKallikrein
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分类

  • {SNA} 3.4.x.x Peptidases, 3.x.x.x Hydrolases, Application Index, Biochemicals and Reagents, Enzyme Class Index, Kallikrein, Plasma & Blood Proteins, Plasma, Blood, and Related Proteins and Reagents, Proteases, Proteases & Protein Sequencing, Proteins and Derivatives, Serum Proteins and Related Enzymes

相关文献及参考

  • Cochrane, C.G., Griffin, J.H., Molecular assembly in the contact phase of the Hageman factor system. Am. J. Med. 67 , 657-664, (1979) 摘要
  • Brunnee, T., et al., Mast cell derived heparin activates the contact system: a link to kinin generation in allergic reactions. Clin. Exp. Allergy 27 , 653-663, (1997)
  • Chavakis, T., et al., Inhibition of platelet adhesion and aggregation by a defined region (Gly-486-Lys-502) of high molecular weight kininogen. J. Biol. Chem. 277 , 23157-23164, (2002) 摘要
  • Renne, T. , Muller-Esterl, W., Cell surface-associated chondroitin sulfate proteoglycans bind contact phase factor H-kininogen. FEBS Lett. 500 , 36-40, (2001) 摘要
  • Zhang, J.C., et al., Two-chain high molecular weight kininogen induces endothelial cell apoptosis and inhibits angiogenesis: partial activity within domain 5. FASEB J. 14 , 2589-2600, (2000)

安全信息

WGK Germany3
RTECSNZ2017050
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US) Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US)
Hazard Codes B 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >40 mL/kg
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - other changes
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 27,2589,1993

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >40 mL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 27,2589,1993

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >40 mL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 27,2589,1993

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >40 mL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 27,2589,1993

{haz

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 210 ku/kg
SEX/DURATION            : female 19-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - parturition
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 47,319,1976

系列性分类

  1. Bradykinins - Peptides for Cell Biology
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Application Index - Enzymes, Inhibitors, and Substrates
  5. Proteases & Protein Sequencing - Application Index
  6. Proteases - Proteases & Protein Sequencing
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Class Index - Enzymes, Inhibitors, and Substrates
  5. 3.x.x.x Hydrolases - Enzyme Class Index
  6. 3.4.x.x Peptidases - 3.x.x.x Hydrolases
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Class Index - Enzymes, Inhibitors, and Substrates
  5. 3.x.x.x Hydrolases - Enzyme Class Index
  6. 3.4.x.x Peptidases - 3.x.x.x Hydrolases
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Proteins and Derivatives - Biochemicals and Reagents
  4. Plasma & Blood Proteins - Proteins and Derivatives
  5. Plasma, Blood, and Related Proteins and Reagents - Plasma & Blood Proteins
  6. Kallikrein - Plasma, Blood, and Related Proteins and Reagents
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Proteins and Derivatives - Biochemicals and Reagents
  4. Plasma & Blood Proteins - Proteins and Derivatives
  5. Plasma, Blood, and Related Proteins and Reagents - Plasma & Blood Proteins
  6. Kininogen - Plasma, Blood, and Related Proteins and Reagents
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Application Index - Enzymes, Inhibitors, and Substrates
  5. Cell Signaling Enzymes - Application Index
  6. Proteasome, Calpain and Lysosomal Proteases - Cell Signaling Enzymes
  7. Lysosomal Proteases - Proteasome, Calpain and Lysosomal Proteases
  8. Cathepsin H - Lysosomal Proteases
  9. Inhibitors - Cathepsin H

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