Indole-7-carboxaldehyde 吲哚-7-甲醛

CAS 1074-88-0 MFCD01318152

化学结构图

1074-88-0
SMILES: O=Cc1cccc2cc[nH]c12

化学属性

Mol. FormulaC9H7NO
Mol. Weight145.16
Melting Point87-91°C
TSCANo
Solubility不溶
Stability对空气敏感
Boiling Point339.1±15.0 °C at 760 mmHg

别名和识别编码

Chemical NameIndole-7-carboxaldehyde
CAS Number1074-88-0
Synonym 1H-Indole-7-carbaldehyde {LY} 1H-Indole-7-carbaldehyde {} {LY} 1H-Indole-7-carbaldehyde {} {} {LY} 1H-Indole-7-carbaldehyde {} {} {} {LY} 1H-Indole-7-carbaldehyde {} {} {} {} {LY} 1H-Indole-7-carbaldehyde {} {} {} {} {} {LY} 1H-Indole-7-carbaldehyde {} {} {} {} {} {} {LY} 1H-Indole-7-carbaldehyde {} {} {} {} {} {} {} {LY} 1H-Indole-7-carbaldehyde {} {} {} {} {} {} {} {} {LY} 1H-Indole-7-carbaldehyde {} {} {} {} {} {} {} {} {} {LY} 1H-Indole-7-carbaldehyde {} {} {} {} {} {} {} {} {} {} {LY} 1H-Indole-7-carbaldehyde {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1H-Indole-7-carbaldehyde {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1H-Indole-7-carbaldehyde {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1H-Indole-7-carbaldehyde {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1H-Indole-7-carbaldehyde {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1H-Indole-7-carbaldehyde {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD01318152
PubChem Substance ID2734629
Beilstein Registry Number1524960
Chemical Name Translation吲哚-7-甲醛
InChIInChI=1S/C9H7NO/c11-6-8-3-1-2-7-4-5-10-9(7)8/h1-6,10H
LabNetwork Molecule IDLN00221400
Canonical SMILESO=CC1=CC=CC2=C1NC=C2
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分类

  • {SNA} Aldehydes, Building Blocks, C7 to C9, C9, Carbonyl Compounds, Chemical Synthesis, Heterocyclic Building Blocks, Indoles, Organic Building Blocks
  • Aldehydes, Building Blocks, C7 to C9, C9, Carbonyl Compounds, Chemical Synthesis, Heterocyclic Building Blocks, Indoles, Organic Building Blocks

产品应用

  • Used in an efficient synthesis of fused pyrroloquinolinedicarboxylates from acetylenedicarboxylates and triphenylphosphine.
  • 1.reactant for preparation of antiandrogens.
  • 2.reactant for preparation of antiplatelet agent.
  • 3.reactant for preparation of liver X receptor (LXR) agonists.
  • 4.reactant for preparation of antagonists of the EP3 receptor for prostaglandin E2.
  • 5.reactant for preparation of inhibitors of glycoprotein perforin.
  • 6.reactant for preparation of potent antitubulin agents.
  • 7.reactant for preparation of potential insulin receptor activators.
  • 8.reactant for preparation of potential scaffolds for peptide mimetics.
  • 9.reactant for preparation of 5-Hydroxytryptamine1D receptor antagonist.
  • 10.reactant for preparation of indolocarbazole kinase inhibitors.

相关文献及参考

  • 1. Zhou, J.; et al. Invest. New Drugs 28 , 291, (2010) 摘要
  • 2. Singh, J.; et al. J. Med. Chem. 53 , 18, (2010)
  • 3. Nilsson, A.; et al. Bioorg. Med. Chem. 17 , 3519, (2009)
  • 4. Singh, J.; et al. ACS Chem. Biol. 4 , 115, (2009)
  • 5. Lena, G.; et al. J. Med. Chem. 51 , 7614, (2008)
  • 6. Liou, J.; et al. J. Med. Chem. 50 , 4548, (2007)
  • 7. Chou, S.; et al. Tetrahedron Lett. 47 , 7579, (2006)
  • 8. Reggelin, M.; et al. J. Am. Chem. Soc. 128 , 4023, (2006)
  • 9. Ward, S., E.; et al. J. Med. Chem. 48 , 3478, (2005)
  • 10. Al-awar, R., S.; et al. Bioorg. Med. Chem. Lett. 14 , 3925, (2004)
  • 11. Monatsh. Chem 137 , 207, (2006)

安全信息

GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P317
  • P302+P352
  • P305+P351+P338
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P317
  • P333+P313
  • P337+P317
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H319 Causes serious eye irritation 严重刺激眼睛
Hazard Codes Xn
WGK Germany3
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S37 Wear suitable gloves 戴适当手套；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
Storage condition 2-8°C, stored under nitrogen {LY} 2-8°C, stored under nitrogen Air Sensitive Keep Cold {} {LY} 2-8°C, stored under nitrogen {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitro

其他信息

  • Alfa Aesar:吲哚-7-甲醛,98% Indole-7-carboxaldehyde, 98%(1074-88-0)
  • 敏感性:Air Sensitive
  • Sigma Aldrich:1074-88-0(sigmaaldrich)
  • 吲哚-7-甲醛价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 366620050 吲哚-7-甲醛 Indole-7-carboxaldehyde 98% 5 GR 6110元 2010/06/21 366620010 吲哚-7-甲醛 Indole-7-carboxaldehyde 98% 1 GR 1586元 2010/06/21 366625000 吲哚-7-甲醛 Indole-7-carboxaldehyde 98% 500 MG 1015元
  • F:10
  • MOL 文件:1074-88-0.mol
  • 上游原料:N,N-二甲基甲酰胺 --> 氢化铝锂 --> 二氧化锰 --> N,N-二甲基甲酰胺二甲基缩醛 --> 三氯化钛 --> 3-甲基-2-硝基苯甲酸
  • Acros Organics:吲哚-7-甲醛 Indole-7-carboxaldehyde, 98%(1074-88-0)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Indazoles 吲唑
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Indoles 吲哚
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Indolines 吲哚啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Aldehydes - Carbonyl Compounds
  6. C9 - Aldehydes
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. D - Alphabetic
  5. DA - DH - D

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