Antide
CAS 112568-12-4 MFCD00133104
化学结构图
SMILES: CC(=O)N[C@H](CC1C=C2C=CC=CC2=CC=1)C(=O)N[C@H](CC1C=CC(Cl)=CC=1)C(=O)N[C@H](CC1=CN=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCNC(=O)C1=CN=CC=C1)C(=O)N[C@H](CCCCNC(=O)C1C=NC=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O
化学属性
| Mol. Formula | C82H108ClN17O14 |
|---|---|
| Mol. Weight | 1591.29 |
别名和识别编码
| Chemical Name | Antide |
|---|---|
| MDL Number | MFCD00133104 |
| PubChem Substance ID | 24891367 |
| CAS Number | 112568-12-4 |
| Synonym | Antide ORF 23541 |
| Beilstein Registry Number | 4866881 |
| Chemical Name Translation |
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分类
- {SNA} LH-RH, Neuropeptides, Peptides and Proteins, Peptides for Cell Biology, Releasing Factors, 细胞信号转导和神经科学, 细胞生物学
- AN-AZ, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, LH-RH, Neuropeptides, Peptides and Proteins, Peptides for Cell Biology, Releasing Factors
- {SNA} AN-AZ, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, LH-RH, Neuropeptides, Peptides and Proteins, Peptides for Cell Biology, Releasing Factors
相关文献及参考
- Kang, S.K., et al., Role of gonadotropin-releasing hormone as an autocrine growth factor in human ovarian surface epithelium. Endocrinology 141 , 72-80, (2000) 摘要
- Nelson,S., et al., Characterization of an intrinsically fluorescent gonadotropin-releasing hormone receptor and effects of ligand binding on receptor lateral diffusion. Endocrinology 140 , 950-957, (1999) 摘要
- Ljungqvist, A., et al, Antide and related antagonists of luteinizing hormone release with long action and oral activity. Proc. Natl. Acad. Sci. U. S. A. 85 , 8236-8240, (1988) 摘要
安全信息
GHS Symbol
- P308+P313
- P201 Obtain special instructions before use. 使用前获取专门指示。
- H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S22 Do not breathe dust 不要吸入粉尘；
- S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
- R60 May impair fertility 可能降低生殖能力
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 750 ug/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects REFERENCE : CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 44,209,1991
TYPE OF TEST : TD
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 1500 ug/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 44,209,1991
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 200 ug/kg SEX/DURATION : female 8-11 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects REFERENCE : CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 44,209,1991
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Primate - monkey DOSE : 10 mg/kg SEX/DURATION : male 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - other effects on male Endocrine - androgenic REFERENCE : CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 45,155,1992
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