Narasin from Streptomyces auriofaciens
CAS 55134-13-9 MFCD00133653
化学结构图
SMILES: C[C@]1(CC[C@]2(O1)O[C@]1(C=CC2O)O[C@H]([C@@H](CC)C(=O)[C@@H](C)[C@@H](O)[C@H](C)[C@@H]2O[C@@H]([C@@H](CC)C(O)=O)[C@@H](C)C[C@@H]2C)[C@@H](C)C[C@H]1C)[C@H]1CC[C@](O)(CC)[C@H](C)O1
化学属性
| Mol. Formula | C43H72O11 |
|---|---|
| Mol. Weight | 765.03 |
别名和识别编码
| Chemical Name | Narasin from Streptomyces auriofaciens |
|---|---|
| CAS Number | 55134-13-9 |
| Synonym | A 28086A Narasin A (4S)-4-Methylsalinomycin Monteban Narasin Narasin from Streptomyces auriofaciens C 7819B Antibiotic A-28086 factor A Compound 79891 Narasul Antibiotic A 28086A 4-Methylsalinomycin Antibiotic C 7819B |
| MDL Number | MFCD00133653 |
| PubChem Substance ID | 24897476 |
| Wiswesser Line Notation | T6XOX DHJ DQ A-& BT6OXTJ C1 E1 FY2&VY1&YQY1&- BT6OTJC1 E1 FY2&VQ&& C-& BT5OXTJ E1 E- FT6OTJ |
| Beilstein Registry Number | 1678311 |
| Chemical Name Translation |
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分类
- Chiral Reagents
- Heterocycles
- {SNA} Antibacterial, Antibiotics A to Z, Antibiotics N-S, Interferes with Cell Membrane Permeability (Ionophores), L - Z, Mechanism of Action, Spectrum of Activity, 抗生素, 生化试剂
- Pharmaceuticals
- Intermediates & Fine Chemicals
- {SNA} Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Interferes with Cell Membrane Permeability (Ionophores), L - Z, Mechanism of Action, Spectrum of Activity
产品应用
- Narasin is the main component of a polyether antibiotic complex produced by Streptomyces auriofaciens NRRL 5758 & NRRL 8092. Ionophoric antibiotic which inhibits coccidial infection in poultry and mam
相关文献及参考
- Berg, D.H., et al.: J. Antibiot., 31, 1 (1978),
- Ruff, M.D., et al.: Poult. Sci., 59, 2008 (1980),
安全信息
GHS Symbol
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P301+P310
- H300 Fatal if swallowed 吞食致命
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- R28 Very toxic if swallowed 吞咽极毒
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >400 mg/m3/30M TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 36,318,1994
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1960 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea REFERENCE : VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 36,318,1994
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >10 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea REFERENCE : VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 36,318,1994
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 15500 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behaviora
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