L-Tetrahydrofolic Acid 四氢叶酸
CAS 135-16-0 MFCD00135583
化学结构图
SMILES: Nc1nc(=O)c2c([nH]1)NCC(CNc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1)N2
化学属性
| Mol. Formula | C19H23N7O6 |
|---|---|
| Mol. Weight | 445 |
别名和识别编码
| Chemical Name | L-Tetrahydrofolic Acid |
|---|---|
| CAS Number | 135-16-0 |
| Synonym | Tetrahydrofolic acid N-[4-[[(2-Amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid THFA (-)-L-5,6,7,8-Tetrahydrofolic Acid 5,6,7,8-四氢蝶酰基-L-谷氨酸 THF 四氢叶酸 5,6,7,8-四氢蝶酰基-L-谷氨酸 Tetrahydropteroylglutamic Acid THF Tetrahydropteroylglutamic acid 5,6,7,8-Tetrahydrofolic acid |
| MDL Number | MFCD00135583 |
| PubChem Substance ID | 135444742 |
| Beilstein Registry Number | 9238187 |
| EC Number | 205-181-1 |
| Chemical Name Translation | 四氢叶酸 |
| InChI | InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t11?,12-/m0/s1 |
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分类
- {SNA} Cofactor, Cofactors, Folic, Oxidation-Reduction, 代谢组学, 代谢通路, 代谢通路图中的代谢产物和辅酶分子, 叶酸代谢, 生化试剂, 细胞生物学, 酶、抑制剂和底物
- {SNA} Cofactor, Cofactors, Folic, Oxidation-Reduction, 代谢组学, 代谢通路, 代谢通路图中的代谢产物和辅酶分子, 叶酸代谢, 生化试剂, 细胞生物学,
- {SNA} Biochemicals and Reagents, Cofactor, Cofactors, Enzymes, Inhibitors, and Substrates, Folic,
产品应用
- A folic acid derivative and coenzyme involved in the metabolism of amino and nucleic acids.
相关文献及参考
- Breaker RR., Prospects for riboswitch discovery and analysis. Mol. Cell. 43 , 867-879, (2011) 摘要
- Fowler B., The folate cycle and disease in humans. Kidney Int. (Suppl.) 78 , S221-229, (2001)
- Graber JR, Breznak JA., Folate cross-feeding supports symbiotic homoacetogenic spirochetes. Appl. Environ. Microbiol. 71 , 1883-1889, (2005) 摘要
- Huang L, Ishibe-Murakami S, et al., Long-range pseudoknot interactions dictate the regulatory response in the tetrahydrofolate riboswitch. Proc. Natl. Acad. Sci. U. S. A. 108 , 14801-14806, (2011) 摘要
- Prinz-Langenohl, R., et al.: Brit. J. Pharmacol., 158, 2014 (2009),
- Ragsdale SW., Catalysis of methyl group transfers involving tetrahydrofolate and B(12). Vitam. Horm. 79 , 293-324, (2008) 摘要
- Scrutton NS, Leys D., Crystal structure of DMGO provides a prototype for a new tetrahydrofolate-binding fold. Biochem. Soc. Trans. 33 , 776-779, (2005) 摘要
- Selhub J., Folate, vitamin B12 and vitamin B6
安全信息
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE : 70 mg/kg SEX/DURATION : female 7-13 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,1132,1973
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 70 mg/kg SEX/DURATION : female 8-14 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - physical REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,1132,1973
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