9,10-Ethanoanthracene-9-(10H)-methylamine, N-methyl-,hydrochloride
CAS 10085-81-1 MFCD00137457
化学结构图
SMILES: Cl.CNC[C@@]12CC[C@@H](C3C=CC=CC1=3)C1C=CC=CC2=1 |&1:4,7|
化学属性
| Mol. Formula | C18H19N.ClH |
|---|---|
| Mol. Weight | 285.84 |
别名和识别编码
| Chemical Name | 9,10-Ethanoanthracene-9-(10H)-methylamine, N-methyl-,hydrochloride |
|---|---|
| CAS Number | 10085-81-1 |
| Synonym | N-Methylethanoanthracene-9-(10H)-methylamine hydrochloride Benzoctamine hydrochloride Tracitin N-Methyl-9,10-ethanoanthracene-9(10H)-methanamine Hydrochloride 1-Methylaminomethyldibenzo(b,c)bicyclo(2,2,2)octadiene hydrochloride Tacitin BA 30,803 |
| Wiswesser Line Notation | L6 H666/GP 2AF P&&TTJ G1M1 &GH |
| Chemical Name Translation |
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资金保障
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分类
- Amines
- Aromatics
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- Anxiolytic.
相关文献及参考
- [2]. Przegaliński E, et al. On the central antiserotonin activity of benzoctamine and opipramol. Pol J Pharmacol Pharm. 1978;30(6):781-790.
- Geisler, L., et al.: Arzneim.-Forsch., 20, 957 (1970),
- Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971),
- [1]. Lippmann W, et al. Effects of benzoctamine and chlordiazepoxide on turnover and uptake of 5-hydroxytryptamine in the brain. Br J Pharmacol. 1974;51(4):571-575.
- [1]. Lippmann W, et al. Effects of benzoctamine and chlordiazepoxide on turnover and uptake of 5-hydroxytryptamine in the brain. Br J Pharmacol. 1974;51(4):571-575.
- [2]. Przegaliński E, et al. On the central antiserotonin activity of benzoctamine and opipramol. Pol J Pharmacol Pharm. 1978;30(6):781-790.
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 26 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,336,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 700 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE : 51 mg/kg SEX/DURATION : female 2-18 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale. (Casa Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy) V.2- 1927- Volume(issue)/page/year: 49,1309,1973
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