Harmine hydrochloride 盐酸去氢骆驼蓬碱

CAS 343-27-1 MFCD00012641

化学结构图

343-27-1
SMILES: COc1ccc2c(c1)[nH]c1c(C)nccc12.Cl

化学属性

Mol. FormulaC13H13ClN2O
Mol. Weight248.71
Melting Point265-270 °C

别名和识别编码

Chemical NameHarmine hydrochloride
MDL NumberMFCD00012641
CAS Number343-27-1
EC Number206-443-8
Synonym Harmine (hydrochloride) {LY} Harmine (hydrochloride) {} {LY} Harmine (hydrochloride) {} {} {LY} Harmine (hydrochloride) {} {} {} {LY} Harmine (hydrochloride) {} {} {} {} {LY} Harmine (hydrochloride) {} {} {} {} {} {LY} Harmine (hydrochloride) {} {} {} {} {} {} {LY} Harmine (hydrochloride) {} {} {} {} {} {} {} {LY} Harmine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Harmine (hydrochloride) {} {} {} {} {} {} {} {} {} {LY} Harmine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Harmine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {LY} Harmine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {LY} Harmine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Harmine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Harmine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Harmine (hy
PubChem Substance ID87570466
Chemical Name Translation盐酸去氢骆驼蓬碱
Reaxys-RN3728837
Merck Number4616
Beilstein Registry Number23,400
Wiswesser Line NotationT B656 EN HMJ F1 KO1 &GH
LabNetwork Molecule IDLN00200127
InChIInChI=1S/C13H12N2O.ClH/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13;/h3-7,15H,1-2H3;1H
Canonical SMILESCC1=NC=CC2=C1NC3=C2C=CC(OC)=C3.Cl
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分类

  • {SNA} Cell Biology, Cell Signaling and Neuroscience, Neurobiology, Neuroscience, Pharmacologicals, Stimulants

产品应用

  • A fluorescent harmala alkaloid and CNS stimulant.

相关文献及参考

  • [2]. Neumann F, et al. DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives. Sci Rep. 2018 Feb 12;8(1):2859.
  • [3]. Zhang L, et al. Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells. Cancer Biol Ther. 2015;16(11):1585-92.
  • [4]. Zhong Z, et al. Treatment with harmine ameliorates functional impairment and neuronal death following traumatic brain injury. Mol Med Rep. 2015 Dec;12(6):7985-91.
  • [1]. Glennon RA, et al. Binding of beta-carbolines and related agents at serotonin (5-HT(2) and 5-HT(1A)), dopamine (D(2)) and benzodiazepine receptors. Drug Alcohol Depend. 2000 Aug 1;60(2):121-32.
  • [1]. Glennon RA, et al. Binding of beta-carbolines and related agents at serotonin (5-HT(2) and 5-HT(1A)), dopamine (D(2)) and benzodiazepine receptors. Drug Alcohol Depend. 2000 Aug 1;60(2):121-32.
  • [2]. Neumann F, et al. DYRK1A inhibition and cognit

安全信息

GHS Symbol
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310+P330
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P403+P233
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P405 Store locked up. 上锁保管。
  • P308+P311
  • P304+P340+P311
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P302+P352+P312+P361+P364
Hazard statements
  • H301+H311+H331
  • H332 Harmful if inhaled 吸入有害
  • H351 Suspected of causing cancer 怀疑致癌
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
WGK Germany3
Signal word
RTECSMG9450000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
UN Number 1544
Packing GroupIII
Hazard Codes Xn
Hazard Class6.1
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 38 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 79,127,1943

Storage condition 2-8°C, sealed storage, away from moisture {LY} 2-8°C, sealed storage, away from moisture {} {LY} 2-8°C, sealed storage, away from moisture {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from mo

其他信息

  • 类别:有毒物质
  • 毒性分级:高毒
  • color:off-white to pale green
  • TCI Shanghai:哈尔明盐酸盐 Harmine Hydrochloride,>;98.0%(LC)(T)(343-27-1)
  • 可燃性危险特性:可燃, 燃烧时分解有毒氯化物, 氮氧化物气体
  • MOL 文件:343-27-1.mol
  • 储运特性:库房低温, 通风, 干燥; 与食品原料分开存放
  • 图谱信息:哈尔碱盐酸盐(水合)(343-27-1)核磁图( 1 HNMR) 哈尔碱盐酸盐(水合)(343-27-1)红外图谱(IR1)
  • Sigma Aldrich:343-27-1(sigmaaldrich)
  • 灭火剂:水, 二氧化碳, 泡沫, 砂土
  • 哈尔碱盐酸盐(水合)价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 H0002 哈尔碱盐酸盐 Harmine Hydrochloride 1G 872元 2014/06/02 H0002 哈尔碱盐酸盐 Harmine Hydrochloride 100MG 292元
  • 急性毒性:静脉- 小鼠 LD50: 38 毫克/公斤

系列性分类

  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Alkaloids
  1. Medical Research Areas
  2. GPCR & G Protein
  3. 5-HT Receptor  (5-羟色胺受体)

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