TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Kidney, Ureter, Bladder - interstitial nephritis REFERENCE : JCHOAM Journal of Chemotherapy. (Philadelphia, PA) V.4-11(1), 1927-34. Volume(issue)/page/year: 10,77,1934
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Human - child DOSE/DURATION : 650 ug/kg TOXIC EFFECTS : Kidney, Ureter, Bladder - urine volume decreased REFERENCE : AMDCA5 AMA Journal of Diseases of Children. (Chicago, IL) V.91-99, 1956-60. For publisher information, see AJDCAI. Volume(issue)/page/year: 97,384,1959
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Human - child DOSE/DURATION : 43 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - urine volume decreased REFERENCE : JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year: 31,580,1947
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 47222 mg/kg/22W-I TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) REFERENCE : JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 198,187,1966
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intramuscular