Calcium Ionophore A23187 hemimagnesium salt Calcium Ionophore A23187

CAS 72124-77-7 MFCD00151203

化学结构图

72124-77-7
SMILES: C[C@@H]1CC[C@]2(O[C@@H]1CC1=NC3C(=C(C=CC=3O1)NC)C(=O)O[Mg]OC(=O)C1C3N=C(C[C@H]4O[C@@]5(CC[C@H]4C)O[C@H]([C@H](C)C(=O)C4=CC=CN4)[C@H](C)C[C@H]5C)OC=3C=CC=1NC)O[C@H]([C@H](C)C(=O)C1=CC=CN1)[C@H](C)C[C@H]2C

化学属性

Mol. FormulaC29H36Mg0.5N3O6
Mol. Weight534.77

别名和识别编码

Chemical NameCalcium Ionophore A23187 hemimagnesium salt
Synonym A23187 Antibiotic A 23187 Calcimycin hemimagnesium salt Calimycin 半镁盐 Calcium Ionophore A23187
MDL NumberMFCD00151203
PubChem Substance ID24893158
Beilstein Registry Number6765085
CAS Number72124-77-7
Chemical Name TranslationCalcium Ionophore A23187
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分类

  • A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Bioactive Small Molecules, C-CH, Calcium Ionophores, Calcium Signaling Research Tools, Cell Biology, Cell Signaling and Neuroscience, Interferes with Cell Membrane Permeability (Ionophores), Intracellular Calcium Signaling, Mechanism of Action, Spectrum of Activity
  • {SNA} A - K, Antibacterial, Antibiotics A to Z, Antibiotics A-F, Calcium Ionophores, Calcium Signaling Research Tools, Interferes with Cell Membrane Permeability (Ionophores), Intracellular Calcium Signaling, Mechanism of Action,

相关文献及参考

  • Kauffman, R.F., et al., Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria. J. Biol. Chem. 255 , 2735-2739, (1980) 摘要
  • Knowles, R.G., and Moncada, S., Nitric oxide as a signal in blood vessels. Trends Biochem. Sci. 17 , 399-402, (1992)
  • Markram, H., and Segal, M., Calcimycin potentiates responses of rat hippocampal neurons to N-methyl-D-aspartate. Brain Res. 540 , 322-324, (1991) 摘要
  • Pressman, B.C., et al., Biological applications of ionophores. Annu. Rev. Biochem. 45 , 50-530, (1976)

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
Hazard statements
  • H332 Harmful if inhaled 吸入有害
  • H315 Causes skin irritation 会刺激皮肤
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H319 Causes serious eye irritation 严重刺激眼睛
Hazard Codes Xn
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害

系列性分类


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