Hydrocortisone sodium phosphate 氢化可的松磷酸钠

CAS 6000-74-4 MFCD00152562

化学结构图

6000-74-4
SMILES: C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@]2(O)C(=O)COP(=O)([O-])[O-].[Na+].[Na+]

化学属性

Mol. FormulaC21H29O8P.2Na
Mol. Weight486.45

别名和识别编码

Chemical NameHydrocortisone sodium phosphate
EC Number227-843-9
Synonym Physiocortison Efcortesol Hydrocortisone sodium phosphate Cortisol sodium phosphate Hydrocortisone disodium phosphate (11b)-11,17-Dihydroxy-21-(phosphonooxy)pregn-4-ene-3,20-dione disodium salt Hydrocortisone 21-phosphate disodium salt CORTISOL SODIUM PHOSPHATE Hydrocortisone 21-disodium salt Hydrocortisone 21-sodium phosphate Hydrocortisone 21-disodium phosphate Hydrocortone phosphate 赖甲环素 HYDROCORTISONE SODIUM PHOSPHATE 4-PREGNEN-11-BETA, 17,21-TRIOL-3,20-DIONE-21-PHOSPHATE SODIUM SALT Cortisol 21-phosphate disodium salt (6CI) Hydrocortisone 21-phosphate disodium Cortisol, 21-(dihydrogen phosphate), disodium salt (7CI, 8CI) Pregn-4-ene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11beta)- Pregn-4-ene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium SODIUM HYDROCORTISONE-21-PHOSPHATE Pregn-4-ene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11β)- hydrocortisone sodium phosphate usp Disodium hydrocortisone 21-phosphate 氢化可的松磷酸钠 Sodium cortisol 21-phosphate Coriphate
CAS Number6000-74-4
MDL NumberMFCD00152562
Chemical Name Translation氢化可的松磷酸钠
Wiswesser Line NotationL E5 B666 OV MUTJ A1 CQ E1 FV1OPWO FQ &-NA- 2
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安全信息

RTECSGM9006000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YAKUD5 Gekkan Yakuji.  Pharmaceuticals Monthly.  (Yakugyo Jihosha, Inaoka
   Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-   1959-
   Volume(issue)/page/year: 21,2117,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 740 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YAKUD5 Gekkan Yakuji.  Pharmaceuticals Monthly.  (Yakugyo Jihosha, Inaoka
   Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-   1959-
   Volume(issue)/page/year: 21,2117,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 632 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 26,379,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YAKUD5 Gekkan Yakuji.  Pharmaceuticals Monthly.  (Yakugyo Jihosha, Inaoka
   Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-   1959-
   Volume(issue)/page/year: 21,2117,1979

TYPE

其他信息

  • MOL 文件:6000-74-4.mol

系列性分类

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