Alaproclate hydrochloride 1-(4-氯苯基)-2-甲基丙-2-基2-氨基丙酸酯盐酸盐
CAS 60719-83-7 MFCD00153761
化学结构图
SMILES: Cl.CC(N)C(=O)OC(C)(C)CC1C=CC(Cl)=CC=1
化学属性
| Mol. Formula | C13H18ClNO2· HCl |
|---|---|
| Mol. Weight | 292.20 |
别名和识别编码
| Chemical Name | Alaproclate hydrochloride |
|---|---|
| Synonym | 2-(4-Chlorophenyl)-1,1-dimethylethyl 2-aminopropanoate hydrochloride Alaproclate hydrochloride DL-Alanine 2-(4-chlorophenyl)-1,1-dimethylethyl ester hydrochloride DL-Alanine, p-chloro-alpha,alpha-dimethylphenethyl ester, hydrochloride GEA-654 hydrochloride |
| CAS Number | 60719-83-7 |
| PubChem Substance ID | 24278076 |
| MDL Number | MFCD00153761 |
| Chemical Name Translation | 1-(4-氯苯基)-2-甲基丙-2-基2-氨基丙酸酯盐酸盐 |
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资金保障
专业采购外包团队在线服务
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分类
- {SNA} Biogenic Amine Transport Inhibitors, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmission (Obesity), Neurotransmitters, 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 肥胖研究, 蛋白质及衍生物
- A-AM, Bioactive Small Molecules, Biochemicals and Reagents, Biogenic Amine Transport Inhibitors, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmission (Obe
相关文献及参考
- Lindberg, U.H., et al., Inhibitors of neuronal monoamine uptake. 2. Selective inhibition of 5-hydroxytryptamine uptake by α-amino acid esters of phenethyl alcohols. J. Med. Chem. 21 , 448, (1978) 摘要
- Orgen, S.O., et al., Alaproclate, a new selective 5-HT uptake inhibitor with therapeutic potential in depression and senile dementia. J. Neural Transm. 59 , 265, (1984) 摘要
- Wilkinson, A., et al., Alaproclate acts as a potentreversible and noncompetitive antagonist of the NMDA receptor coupled ion flow. J. Pharmacol. Exp. Ther. 271 , 1314-1319, (1994) 摘要
- Svensson, B.E., et al., Alaproclate effects on voltage-dependent K + channels and NMDA receptors: studies in cultured rat hippocampal neurons and fibroblast cells transformed with Kv1.2 K + channel cDNA. Neuropharmacology 33 , 795-804, (1994) 摘要
- Ha, Y., et al., Analysis Of Sigma Receptor (sigmaR1) Binding To BiP In Oxidative Stress-Induced Death Of Retinal Ganglion Cells (RGC) Invest. Ophthalmol. Vis. Sci. 50 , 120, (2009)
安全信息
GHS Symbol
- H332 Harmful if inhaled 吸入有害
- H302 Harmful if swallowed 吞食有害
- H312 Harmful in contact with skin 皮肤接触有害
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,448,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 54 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,448,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 901 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,448,1978
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S22 Do not breathe dust 不要吸入粉尘；
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
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