Metoclopramide dihydrochloride monohydrate

CAS 5581-45-3 MFCD01670436

化学结构图

5581-45-3
SMILES: CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC.Cl.Cl.O

化学属性

Mol. FormulaC14H22ClN3O2.2ClH.H2O
Mol. Weight389.77

别名和识别编码

Chemical Nameo-Anisamide,4-amino-5-chloro-N-(2-(diethylamino)ethyl)-,dihydrochloride, monohydrate
Synonym 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-o-anisamide dihydrochloride Cerucal Dihydrochloride, Metoclopramide Hydrochloride, Metoclopramide Maxolon Metaclopramide Metoclopramide Metoclopramide Dihydrochloride Metoclopramide Hydrochloride Metoclopramide Monohydrochloride Metoclopramide Monohydrochloride, Monohydrate Monohydrochloride, Metoclopramide Primperan Reglan Rimetin
CAS Number5581-45-3
PubChem Substance ID656838
InChIInChI=1S/C14H22ClN3O2.2ClH.H2O/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3;;;/h8-9H,4-7,16H2,1-3H3,(H,17,19);2*1H;1H2
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安全信息

RTECSBZ3320000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 633 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AAREAV Anesthesie, Analgesie, Reanimation.  (Paris, France)  V.14-38,
   1957-81.  Volume(issue)/page/year: 23,663,1966

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 335 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 8,3991,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 42100 ug/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 8,3991,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 138 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AAREAV Anesthesie, Analgesie, Reanimation.  (Paris, France)  V.14-38,
   1957-81.  Volume(issue)/page/year: 23,663,1966

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperiton

Hazard statements
  • H302 Harmful if swallowed 吞食有害
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P312
  • P301+P317
  • P330 Rinse mouth. 漱口
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

系列性分类

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