Sydnone imine,3-(alpha-methylphenethyl)-N-(phenylcarbamoyl)-

CAS 34262-84-5 MFCD01682826

化学结构图

34262-84-5
SMILES: CC(CC1C=CC=CC=1)[N+]1=C/C(=N\C(=O)NC2C=CC=CC=2)/O[N-]1

化学属性

Mol. FormulaC18H18N4O2
Mol. Weight322.40

别名和识别编码

Chemical NameSydnone imine,3-(alpha-methylphenethyl)-N-(phenylcarbamoyl)-
CAS Number34262-84-5
Synonym Sydnone imine, 3-(1-methyl-2-phenylethyl)-N-((phenylamino)carbonyl)- Sidnocarb Sidnokarb Mesocarb Sydnocarb ######## 3-(beta-Phenylisopropyl)-N-phenyl carbamoylsidnonimin
Beilstein Registry Number5773701
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分类

  • Amines
  • Aromatics
  • Inhibitors
  • Neurochemicals
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Mesocarb is a CNS stimulant that acts as a dopamine reuptake inhibitor. Mesocarb is a psychotropic drug. Mesocarb is used to counteract the sedative effects of benzodiazepine drugs.

相关文献及参考

  • Gainetdinov, R.R. et al.: Eur. J. Pharmacol., 340, 53 (1997); Kholodov, L.E. et al.: Khim.-Farmat. Zhur., 7, 50 (1973); Valueva, L.N. et al.: Zhur. Nevropatol. Psikh. S. S. Korsak., 82, 1212 (1982);

安全信息

RTECSWU7684000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 36,2,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 410 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KHFZAN Khimiko-Farmatsevticheskii Zhurnal.  Chemical Pharmaceutical Journal.
    For English translation, see PCJOAU.  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR)  V.1-    1967-  Volume(issue)/page/year: 10(12),70,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DBANAD Doklady Bolgarskoi Akademii Nauk.  (Hemus, Blvd. Russki 6, Sofia,
   Bulgaria)  V.1-    1948-  Volume(issue)/page/year: 44(6),97,1991

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