Rifamycin O 利福霉素-O

CAS 14487-05-9 MFCD01683928

化学结构图

14487-05-9
SMILES: C[C@]12OC3=C(C1=O)C1=C(C(=O)C(=CC41OCC(=O)O4)NC(=O)C(C)=CC=C[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@H](C=CO2)OC)C(O)=C3C |c:26,55,t:28,48|

化学属性

Mol. FormulaC39H47NO14
Mol. Weight754

别名和识别编码

Chemical NameRifamycin O
CAS Number14487-05-9
Synonym NSC 182391 4-O-(Carboxymethyl)-1-deoxy-1,4-dihydro-4-hydroxy-1-oxo-rifamycin ?-Lactone 二恶酮利福霉素; 利福霉素-O Rifamycin O Rifamycin, 4-O-(carboxymethyl)-1-deoxy-1,4-dihydro-4-hydroxy-1-oxo-,
EC Number238-493-1
Chemical Name Translation利福霉素-O
MDL Number
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分类

  • Chiral Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Rifaximin intermediate.

相关文献及参考

  • Vohra, R., et al.: Biotechnol. Lett., 11, 851 (1989),
  • Bacchi, A., et al.: J. Med. Chem., 41, 2319 (1998),

安全信息

RTECSWH1306500 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 2,462,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds.,
   Tokyo, Univ. of Tokyo Press, 1967  Volume(issue)/page/year: -,566,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 2,462,1980

系列性分类

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