6-Quinolinecarboxylic acid, 4-nitro-, 1-oxide

CAS 1425-67-8 MFCD01685673

化学结构图

1425-67-8
SMILES: O=C(O)c1ccc2c(c1)c([N+](=O)[O-])cc[n+]2[O-]

化学属性

Mol. FormulaC10H6N2O5
Mol. Weight234.18

别名和识别编码

Chemical Name6-Quinolinecarboxylic acid, 4-nitro-, 1-oxide
Wiswesser Line NotationT66 BNJ BO ENW HVQ
Synonym 4-Nitro-6-quinolinecarboxylic acid 1-oxide 6-Carboxy-4-nitroquinoline-1-oxide 6-Carboxyl-4-nitroquinoline 1-oxide 4-Nitroquinoline-6-carboxylic acid 1-oxide
CAS Number1425-67-8
Beilstein Registry Number0483777
InChIKeyMJCUNRRGIZCINL-UHFFFAOYSA-N
PubChem Substance ID74024
InChIInChI=1S/C10H6N2O5/c13-10(14)6-1-2-8-7(5-6)9(12(16)17)3-4-11(8)15/h1-5H,(H,13,14)
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安全信息

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 120 mg/kg/50D-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   16,631,1967

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 90 mg/kg/20W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   58,397,1967

RTECSVB2275000 
TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 500 ug/well
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   32,2369,1972

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Kidney
DOSE/DURATION           : 100 umol/L
REFERENCE :
   PPTCBY Proceedings of the International Symposium of the Princess Takamatsu
   Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku,
   Tokyo 113, Japan)  1st-    1971-  Volume(issue)/page/year: 2,17,1972

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 100 mg/L
REFERENCE :
   IGSBAL Igaku to Seibutsugaku.  Medicine and Biology.  (c/o Ogato Igaku
   Kagaku Kenkyusho, 2-3-5 Bakuro-cho, Nihonbashi, Chuo-ku, Tokyo 103, Japan)
   V.1-    1942-  Volume(issue)/page/year: 85,127,1972

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - hamster Cells - not otherwise specified
DOSE/DURATION           : 4 umol/L
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 229,416,1971

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 500 ug/well
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   32,2369,1972

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Fibroblast
DOSE/DURATION           : 100 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut

系列性分类

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