3-Quinolinecarboxylic acid,1,4-dihydro-1-cyclopropyl-6,8-difluoro-4-oxo-7-(1-piperazinyl)-

CAS 94242-53-2 MFCD01685677

化学结构图

94242-53-2
SMILES: OC(=O)C1=CN(C2CC2)C2=C(C=C(F)C(=C2F)N2CCNCC2)C1=O

化学属性

Mol. FormulaC17H17F2N3O3
Mol. Weight349.37

别名和识别编码

Chemical Name3-Quinolinecarboxylic acid,1,4-dihydro-1-cyclopropyl-6,8-difluoro-4-oxo-7-(1-piperazinyl)-
Synonym 8-Fluorociprofloxacin 1-Cyclopropyl-6,8-difluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid
Beilstein Registry Number3632527
CAS Number94242-53-2
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安全信息

RTECSVB1993500
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1414 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JHTCAD Journal of Heterocyclic Chemistry. (Hetero Corporation, POB 16000 MH,
   Tampa, FL 33687) Vol.1-    1964-  Volume(issue)/page/year: 26,393,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 126 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   KJTOEA Korean Journal of Toxicology.  (Korean Society of Toxicology, c/o
   College of Medicine, Seoul National University, Seoul, 110, S. Korea)  V.1-
   1985-  Volume(issue)/page/year: 8,161,1993

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 186 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   KJTOEA Korean Journal of Toxicology.  (Korean Society of Toxicology, c/o
   College of Medicine, Seoul National University, Seoul, 110, S. Korea)  V.1-
   1985-  Volume(issue)/page/year: 8,161,1993

系列性分类


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