γ-Hydroxy Phenylbutazone

CAS 568-76-3 MFCD01693333

化学结构图

568-76-3
SMILES: CC(O)CCC1C(=O)N(c2ccccc2)N(c2ccccc2)C1=O

化学属性

Mol. FormulaC19H20N2O3
Mol. Weight324

别名和识别编码

Chemical Nameγ-Hydroxy Phenylbutazone
CAS Number568-76-3
Synonym (+-)-isomer of gamma-hydroxyphenylbutazone 1,2-Diphenyl-3,5-dioxo-4-(3-hydroxybutyl)pyrazolidine 1,2-diphenyl-3,5-dioxo-4-(3-hydroxybutyl)pyrazolidine 3,5-Pyrazolidinedione, 4-(3-hydroxybutyl)-1,2-diphenyl- 4-(3-Hydroxybutyl)-1,2-diphenyl- BM 11 G 28231 gamma-Hydroxyphenylbutazone gamma-hydroxyphenylbutazone
Chemical Name Translation
InChIKeyPPJYQSFRNGSEBH-UHFFFAOYSA-N
Wiswesser Line NotationT5VNNV EHJ BR& CR& E2YQ1
Beilstein Registry Number0309214
MDL Number
PubChem Substance ID120741
InChIInChI=1S/C19H20N2O3/c1-14(22)12-13-17-18(23)20(15-8-4-2-5-9-15)21(19(17)24)16-10-6-3-7-11-16/h2-11,14,17,22H,12-13H2,1H3
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分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • ?-Hydroxy Phenylbutazone is a metabolite of Kebuzone (K155300). Antirheumatic.

相关文献及参考

  • Lam, F., et al.: J. Pharma. Sci., 74, 229 (1985),

安全信息

RTECSUQ8500000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CKFRAY Ceskoslovenska Farmacie.  (PNS-Ustredni Expedice a Dovoz Tisku,
   Kafkova 19, 160 00 Prague 6, Czechoslovakia)  V.1-    1952-
   Volume(issue)/page/year: 21,325,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 623 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
   Behavioral - excitement
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   ANYAA9 Annals of the New York Academy of Sciences.  (New York Academy of
   Sciences, 2 E. 63rd St., New York, NY 10021)  V.1-    1877-
   Volume(issue)/page/year: 86,263,1960

系列性分类

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