Methanesulfonanilide,4'-(9-acridinylamino)-2'-methoxy-

CAS 51264-17-6 MFCD01715402

化学结构图

51264-17-6
SMILES: COC1C=C(C=CC=1NS(C)(=O)=O)NC1=C2C=CC=CC2=NC2C=CC=CC=21

化学属性

Mol. FormulaC21H19N3O3S
Mol. Weight393.49

别名和识别编码

Chemical NameMethanesulfonanilide,4'-(9-acridinylamino)-2'-methoxy-
Wiswesser Line NotationT C666 BNJ IMR CO1 DMSW1
Synonym 4'-(9-Acridinylamino)-2'-methoxymethanesulfonanilide o-Amsa Methanesulfon-o-anisidide, 4'-(9-acridinylamino)- 4'-(9-Acridinylamino)methanesulfon-o-anisidide N-(4-(9-Acridinylamino)-3-methoxyphenyl)methanesulfonamide
CAS Number51264-17-6
Beilstein Registry Number0452140
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安全信息

RTECSPB0505000 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human
DOSE/DURATION           : 34 mg/kg
TOXIC EFFECTS :
   Vascular - thrombosis distant from injection site
   Blood - leukopenia
   Blood - thrombocytopenia
REFERENCE :
   CTRRDO Cancer Treatment Reports.  (Washington, DC)  V.60-71, 1976-87.  For
   publisher information,  see JNCIEQ.  Volume(issue)/page/year: 62,1421,1978

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 250 ug/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Vo

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 50 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 68,295,1979

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Mammal - species unspecified Lymphocyte
DOSE/DURATION           : 100 mmol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   44,53,1983

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 10 umol/L
REFERENCE :
   BICHAW Biochemistry.  (American Chemical Soc., Distribution Office Dept.
   223, POB 57136, West End Stn., Washington, DC 20037)  V.1-    1962-
   Volume(issue)/page/year: 20,6553,1981

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 100 ug/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 2,349,1987

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 162 umol/L
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/y

系列性分类

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