(14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-Chloro-14-Hydroxy-85,14-Dimethoxy-33,2,7,10-Tetramethyl-12,6-Dioxo-7-Aza-1(6,4)-Oxazinana-3(2,3)-Oxirana-8(1,3)-Benzenacyclotetradecaphane-10,12-Dien-4-Yl N-Acetyl-N-Methyl-L-Alaninate (14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-氯-14-羟基-85,14-二甲氧基-33,2,7,10-四甲基-12,6-二氧代-7-氮杂-1(6,4)-恶嗪-3(2,3)-环氧乙烷-8(1,3)-苯并环十四烷-10,12-二烯-4-基-N-乙酰基-N-甲基-L-丙氨酸盐
CAS 35846-53-8 MFCD01715768
化学结构图
SMILES: C[C@]12O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@@H](C=CC=C(C)CC1C=C(OC)C(Cl)=C(C=1)N(C)C(=O)C[C@@H]2OC(=O)[C@H](C)N(C)C(C)=O)OC |c:19,t:17,24|
化学属性
| Mol. Formula | C34H46ClN3O10 |
|---|---|
| Mol. Weight | 692.28 |
别名和识别编码
| Chemical Name | (14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-Chloro-14-Hydroxy-85,14-Dimethoxy-33,2,7,10-Tetramethyl-12,6-Dioxo-7-Aza-1(6,4)-Oxazinana-3(2,3)-Oxirana-8(1,3)-Benzenacyclotetradecaphane-10,12-Dien-4-Yl N-Acetyl-N-Methyl-L-Alaninate |
|---|---|
| Wiswesser Line Notation | T D3 K6-19-6 A K- EO IVN WNVO QU SUTJ C1 GOVY1&N1&V1J1 LG MO1 Q1 UO1 VQ |
| Synonym | Maytansin NSC-153858 |
| Beilstein Registry Number | 5417399 |
| CAS Number | 35846-53-8 |
| Chemical Name Translation | (14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-氯-14-羟基-85,14-二甲氧基-33,2,7,10-四甲基-12,6-二氧代-7-氮杂-1(6,4)-恶嗪-3(2,3)-环氧乙烷-8(1,3)-苯并环十四烷-10,12-二烯-4-基-N-乙酰基-N-甲基-L-丙氨酸盐 |
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
安全信息
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human DOSE/DURATION : 190 ug/kg/5D TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions Behavioral - changes in motor activity (specific assay) Gastrointestinal - nausea or vomiting REFERENCE : JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 60,93,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 480 ug/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 61,1333,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 245 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1530 ug/kg TOXIC EFFECTS : Blood - leukopenia Blood - thrombocytopenia Skin and Appendages - hair REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technic
TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Leukocyte DOSE/DURATION : 100 nmol/L REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 24,751,1975
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - mouse Ascites tumor DOSE/DURATION : 100 ug/kg REFERENCE : JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 60,649,1978
TYPE OF TEST : DNA inhibition TEST SYSTEM : Non-mammalian species Embryo DOSE/DURATION : 60 nmol/L REFERENCE : SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 189,1002,1975
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - mouse Ascites tumor DOSE/DURATION : 100 ug/kg REFERENCE : JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 60,649,1978
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE : 200 ug/kg SEX/DURATION : female 7 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : BIHAA2 Bibliotheca Haematologica (Basel). (S. Karger AG, Postfach, CH-4009 Basel, Switzerland) No.1- 1955- Volume(issue)/page/year: 43,495,1976
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE : 200 ug/kg SEX/DURATION : female 7 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : BIHAA2 Bibliotheca Haematologica (Basel). (S. Karger AG, Postfach, CH-4009 Basel, Switzerland) No.1- 1955- Volume(issue)/page/year: 43,495,1976
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE : 250 ug/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 18,31,1978
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE : 200 ug/kg
京ICP备2020036287号