TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 2400 ug/kg
TOXIC EFFECTS :
   Behavioral - headache
   Gastrointestinal - decreased motility or constipation
   Gastrointestinal - other changes
REFERENCE :
   BDDID8 Biopharmaceutics & Drug Disposition.  (John Wiley & Sons, Baffins
   Lane, Chichester, W. Sussex PO19 1UD, UK)  V.1-    1979-
   Volume(issue)/page/year: 18,361,1997

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 2400 ug/kg/10M-C
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - headache
REFERENCE :
   BDDID8 Biopharmaceutics & Drug Disposition.  (John Wiley & Sons, Baffins
   Lane, Chichester, W. Sussex PO19 1UD, UK)  V.1-    1979-
   Volume(issue)/page/year: 18,361,1997

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 545 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   18,506,1993

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 165 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   18,506,1993