2H-1,3,2-Oxazaphosphorine,2-(bis(2-chloroethyl)amino)-4-hydroxytetrahydro-,2-oxide

CAS 67292-62-0 MFCD01747930

化学结构图

67292-62-0
SMILES: OC1CCOP(N1)N(CCCl)CCCl

化学属性

Mol. FormulaC7H15Cl2N2O3P
Mol. Weight277.11

别名和识别编码

Chemical Name2H-1,3,2-Oxazaphosphorine,2-(bis(2-chloroethyl)amino)-4-hydroxytetrahydro-,2-oxide
Wiswesser Line NotationT6MPOTJ BN2G2G FQ
Synonym 2-(Bis(2-chloroethyl)amino)-4-hydroxytetrahydro-2H-1,3,2-oxazaphosphorine 4-OH-CP 4-Hydroxycyclophosphamide
CAS Number67292-62-0
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安全信息

RTECSRP5925000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 141 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   INNDDK Investigational New Drugs. The Journal of New Anticancer Agents.
   Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018)  V.1- 1983- 
   Volume(issue)/page/year: 2,253,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 139 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 18,376,1975

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 ug/plate
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   42,3016,1982

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 100 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 245,293,1990

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 50 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   44,5156,1984

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 1 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 129,47,1984

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Embryo
DOSE/DURATION           : 1 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   47,5421,1987

系列性分类

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