1,2-Propanediamine, N(sup 1),N(sup 1)-dimethyl-N(sup2)-(1-nitro-9-acridinyl)-, dihydrochloride

CAS 65094-73-7 MFCD01749063

化学结构图

65094-73-7
SMILES: Cl.Cl.CN(C)CC(C)NC1=C2C(=CC=CC2=NC2C=CC=CC=21)[N+]([O-])=O

化学属性

Mol. FormulaC18H20N4O2.2ClH
Mol. Weight397.34

别名和识别编码

Chemical Name1,2-Propanediamine, N(sup 1),N(sup 1)-dimethyl-N(sup2)-(1-nitro-9-acridinyl)-, dihydrochloride
Wiswesser Line NotationT C666 BNJ GNW IMY1&1N1&1 &GH 2
Synonym Acridine, 9-((2-(dimethylamino)-1-methylethyl)amino)-1-nitro,
CAS Number65094-73-7
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安全信息

RTECSTX7955000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 13300 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   27,749,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Bird - pigeon
DOSE/DURATION           : 21 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   28,777,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 99200 ug/kg
TOXIC EFFECTS :
   Gastrointestinal - decreased motility or constipation
   Gastrointestinal - other changes
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   27,749,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 105 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - decreased motility or constipation
   Gastrointestinal - other changes
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   27,749,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERV

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 80 nmol/L/69H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 67,93,1979

系列性分类

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