Phosphinic amide,N,N'-(1,4-phenylenebis(1-aziridinylmethylidyne))bis(P,P-bis(1-aziridinyl)-

CAS 52161-27-0 MFCD01766348

化学结构图

52161-27-0
SMILES: O=P(/N=C(/C1C=CC(=CC=1)/C(=N/P(=O)(N1CC1)N1CC1)/N1CC1)\N1CC1)(N1CC1)N1CC1

化学属性

Mol. FormulaC20H28N8O2P2
Mol. Weight474.50

别名和识别编码

Chemical NamePhosphinic amide,N,N'-(1,4-phenylenebis(1-aziridinylmethylidyne))bis(P,P-bis(1-aziridinyl)-
Synonym N,N'-(1,4-Phenylenebis(1-aziridinylmethylidyne))bis(P,P-bis(1-aziridinyl)phosphinic amide)
Beilstein Registry Number1360788
CAS Number52161-27-0
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安全信息

RTECSSZ5867500 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Liver - hepatitis (hepatocellular necrosis), zonal
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Blood - changes in spleen
REFERENCE :
   FATOBP Farmakologiya i Toksikologiya (Kiev).  Pharmacology and Toxicology.
   (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii,
   Kiev, USSR)  No.1-    1964-  Volume(issue)/page/year: 8,73,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 79 mg/kg
TOXIC EFFECTS :
   Liver - hepatitis (hepatocellular necrosis), zonal
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Blood - changes in spleen
REFERENCE :
   FATOBP Farmakologiya i Toksikologiya (Kiev).  Pharmacology and Toxicology.
   (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii,
   Kiev, USSR)  No.1-    1964-  Volume(issue)/page/year: 8,73,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 25500 ug/kg
TOXIC EFFECTS :
   Liver - hepatitis (hepatocellular necrosis), zonal
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Blood - changes in spleen
REFERENCE :
   FATOBP Farmakologiya i Toksikologiya (Kiev).  Pharmacology and Toxicology.
   (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii,
   Kiev, USSR)  No.1-    1964-  Volume(issue)/page/year: 8,73,1973

系列性分类

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