2-Chloro-N-(p-tolyl)acetamide 2-氯-N-(对甲基苯基)乙酰胺

CAS 16634-82-5 MFCD00018910

化学结构图

16634-82-5
SMILES: CC1=CC=C(C=C1)NC(=O)CCl

化学属性

Mol. FormulaC9H10ClNO
Mol. Weight184
Melting Point164 - 166 (°C)

别名和识别编码

Chemical Name2-Chloro-N-(p-tolyl)acetamide
CAS Number16634-82-5
Alfabeta NameCHLOROMETHYLPHENYLACETAMIDE N24()----
MDL NumberMFCD00018910
Synonym 2-Chloroaceto-p-toluidide 2-Chloro-4-acetotoluidide N-(Chloroacetyl)-p-toluidine 2-Chloro-4'-methylacetanilide p-Toluene chloromethylamide 4-Methyl-alpha-chloroacetanilide p-Methylchloroacetanilide Acetamide, 2-chloro-N-(4-methylphenyl)-
Wiswesser Line NotationGR C1 FMV1
Beilstein Registry Number0638223
Chemical Name Translation2-氯-N-(对甲基苯基)乙酰胺
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分类

  • {KO} ReacChlorides

安全信息

Warnings IRRITANT
RTECSAN3150000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,517,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 320 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#02137

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2740 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,517,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 452 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, In

药物吸收、分布、代谢与排泄(ADME)

Lipinski's Rule of 3
Y
Lipinski's Rule of 5
Y
H-bond Acceptors
1
Rotatable Bonds
2
H-bond Donors
1
LogP
1

系列性分类

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