Olomoucine is a CDK inhibitor that competes for the ATP binding site of the kinase. Olomoucine was shown to reversibly arrest differentiated Petunia cells induced to divide at G1 phase and cycling Arabidopsis cells in late G1 and G2. 2-(2'-羟基乙基氨基)-9-甲基-6-(苄基氨基)嘌呤

CAS 101622-51-9 MFCD00189360

化学结构图

101622-51-9
SMILES: Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc21

化学属性

Mol. FormulaC15H18N6O
Mol. Weight298.34
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameOlomoucine is a CDK inhibitor that competes for the ATP binding site of the kinase. Olomoucine was shown to reversibly arrest differentiated Petunia cells induced to divide at G1 phase and cycling Arabidopsis cells in late G1 and G2.
CAS Number101622-51-9
Synonym 2-(Hydroxyethylamino)-6-benzylamino-9-methylpurine 6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine N2-[(2-Hydroxyethyl)-N6-benzyladenine NSC 666096 Olomoucine
MDL NumberMFCD00189360
PubChem Substance ID24278053
Chemical Name Translation2-(2'-羟基乙基氨基)-9-甲基-6-(苄基氨基)嘌呤
FormulaC15H18N6O
IUPAC Name6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine
InChIKeyGTVPOLSIJWJJNY-UHFFFAOYSA-N
InChIInChI=1S/C15H18N6O/c1-21-10-18-12-13(17-9-11-5-3-2-4-6-11)19-15(16-7-8-22)20-14(12)21/h2-6,10,22H,7-9H2,1H3,(H2,16,17,19,20)
Canonical SMILESCN1C=NC2=C(NCC3=CC=CC=C3)N=C(NCCO)N=C12
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分类

  • Bases & Related Reagents
  • {SNA} A to C, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, Cyclin Dependent Kinases, Cyclin-Dependent Kinase (CDK), Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Kinase/Phosphatase Biology, O,

产品应用

  • Olomoucine is a CDK inhibitor that competes for the ATP binding site of the kinase. Olomoucine was shown to reversibly arrest differentiated Petunia cells induced to divide at G1 phase and cycling Arabidopsis cells in late G1 and G2.

相关文献及参考

  • Vesely, J., et a.: Eur. J. Biochem., 224, 771 (1994),
  • Vesely, J., et al., Inhibition of cyclin-dependent kinases by purine analogues. Eur. J. Biochem. 224 , 771-786, (1994) 摘要
  • Abraham, R.T., et al., Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biol. Cell 83 , 105-120, (1995) 摘要

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. A to C - Enzyme Inhibitors by Enzyme
  7. Cyclin Dependent Kinases - A to C
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Apoptosis and Cell Cycle - Cell Signaling and Neuroscience
  5. Cell Cycle Proteins and Antibodies - Apoptosis and Cell Cycle
  6. Cell Cycle Regulators - Cell Cycle Proteins and Antibodies
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Protein Kinases and Phosphatases
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Apoptosis and Cell Cycle
  5. Cell Cycle
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Kinases and Phosphatases
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Proteins and Derivatives
  4. Proteins for Cell Biology
  5. Kinases and Phosphatases
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Apoptosis and Cell Cycle Proteins
  6. Apoptosis Inhibitors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Proteins for Cell Biology
  6. Immune System Proteins
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Complement Factor D
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Proteins and Derivatives
  4. Proteins for Cell Biology
  5. Apoptosis and Cell Cycle Proteins
  6. Apoptosis Inhibitors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Kinase/Phosphatase Biology
  5. Serine/Threonine Kinase Biology
  6. Serine/Threonine Kinase Inhibitors
  7. Casein Kinase (CK)
  1. Medical Research Areas
  2. Cell Cycle
  3. CDK

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