Actarit 阿克他利
CAS 18699-02-0 MFCD00196165
化学结构图
SMILES: CC(=O)NC1C=CC(CC(O)=O)=CC=1
化学属性
| Mol. Formula | C10H11NO3 |
|---|---|
| Mol. Weight | 193.20 |
| Density | 1.422 |
| Melting Point | 165.0 to 170.0 deg-C |
别名和识别编码
| Chemical Name | Actarit |
|---|---|
| CAS Number | 18699-02-0 |
| Synonym | (p-Acetamidophenyl)acetic acid 4-(Acetylamino)-benzeneacetic acid 4-(Acetylamino)benzeneacetic Acid 4-(Acetylamino)phenylacetic acid Acetic acid, (p-acetamidophenyl)- 4-N-Acetylaminophenylacetic acid 4-Acetamidophenylacetic acid MS 932 4-(Acetylamino)benzeneacetic acid |
| MDL Number | MFCD00196165 |
| EC Number | 242-511-3 |
| Beilstein Registry Number | 1640927 |
| Chemical Name Translation | 阿克他利 |
| Reaxys-RN | 1640927 |
| PubChem Substance ID | 354335683 |
| Merck Number | 133 |
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分类
- Aromatics
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- Antiarthritic.
相关文献及参考
- Stern, R., et al.: N. Engl. J. Med., 309, 186 (1983),
安全信息
GHS Symbol
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5480 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - cyanosis REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 40,117,199
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 14800 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - cyanosis REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1950 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1060 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - cyanosis REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 40,117,1990
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 33 gm/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 40,279,1990
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