2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine 2-氨基-1-甲基-6-苯基咪唑并[4,5-b]吡啶

CAS 105650-23-5 MFCD00210745

化学结构图

105650-23-5
SMILES: CN1C(N)=NC2N=CC(=CC1=2)C1C=CC=CC=1

化学属性

Mol. FormulaC13H12N4
Mol. Weight224.29

别名和识别编码

Chemical NameImidazo(4,5-b)pyridine, 2-amino-1-methyl-6-phenyl-
CAS Number105650-23-5
Synonym 1H-Imidazo(4,5-b)pyridine, 2-amino-1-methyl-6-phenyl- PhIP 1-Methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-amine 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine 1H-Imidazo(4,5-b)pyridin-2-amine, 1-methyl-6-phenyl-
Chemical Name Translation2-氨基-1-甲基-6-苯基咪唑并[4,5-b]吡啶
Wiswesser Line NotationT56 BN DN FNJ B1 CZ HR
Beilstein Registry Number5951264
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分类

  • Mutagenesis Research Chemicals
  • Nucleotides
  • Bases & Related Reagents

产品应用

  • Carcinogen

相关文献及参考

  • Knize, M.G., et al: Envir. Health Perspectives, 67, 17 (1986),
  • Stavric, B., et al.: Fd. Chem. Toxic., 31, 981 (1993),
  • Sugimura, T., et al.: Mutation Res., 290, 43 (1993),

安全信息

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4200 mg/kg/44W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB
   211, 1000 AE Amsterdam, Netherlands)  V.76-    1985-
   Volume(issue)/page/year: 82,363,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 37056 mg/kg/83W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB
   211, 1000 AE Amsterdam, Netherlands)  V.76-    1985-
   Volume(issue)/page/year: 80,1176,1989

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 449 mg/kg/8W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 16,431,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 8736 mg/kg/52W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 12,1503,1991

RTECSNJ5199900 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Liver
DOSE/DURATION           : 5 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 371,273,1996

TYPE OF TEST            : Mutation in microorganisms
T

TYPE OF TEST            : DNA adduct
TEST SYSTEM

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 10 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 367,115,1996

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 1 mg/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 2,483,1987

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 3360 mg/kg/16W (Continuous)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 5 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 371,23,1996

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 10 umol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 10,1389,1989

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系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyridines 吡啶

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