Metoclopramide 甲氧氯普胺

CAS 364-62-5 MFCD00211338

化学结构图

364-62-5
SMILES:

化学属性

Mol. FormulaC14H22ClN3O2
Mol. Weight300
Appearance 该品二盐酸盐一水合物([7232-21-5])熔点145℃(分解),溶于水、甲醇,稍少溶于乙醇。在酸性溶液中稳定。该品一盐酸盐一水合物([54143-57-6])为白色结晶性粉末,熔点182.5-184℃。
Melting Point147.0 to 151.0 deg-C

别名和识别编码

Chemical NameMetoclopramide
CAS Number364-62-5
Synonym 5-Chloro-2-methoxyprocainamide 氯普胺 ######## 胃复安 Plasil Metoclol 4-氨基-5-氯-N-[2-(二乙氨基)乙基]-2-甲氧基苯甲酰胺 Reliveran 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide 2-Methoxy-5-Chloroprocainamide Metocobil Primperan 2-Methoxy-5-chloroprocainamide del1267 Methochlopramide 甲氧氯普胺 甲氧普胺 4-氨基-5-氯-N-[(2-二乙氨基)乙基]-2-甲氧基苯酰胺 DEL 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-o-anisamid 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide Methoxychloroprocainamide Moriperan Methoclopramide N-[(2-二乙氨基)乙基]-4-氨基-2-甲氧基-5-氯-苯甲酰胺 Anisamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)- 4-Amino-5-Cholo-N-[(2-diethylamino)ethyl]-2-methyloxy-benzamide Metramid Metoclopranide DEL 1267 o-Anisamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)- Metaclopromide Metochlopramide 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-n-anisamid Metaclopramide 灭吐灵 灭吐宁 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide monohydrochloride Metoclopramide 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-2-methoxy-benzamid Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxy- N-(Diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide
EC Number206-662-9
MDL NumberMFCD00211338
Beilstein Registry Number1884366
Reaxys-RN1884366
Merck Number6143
Chemical Name Translation甲氧氯普胺
Wiswesser Line Notation2N2&2MVR DZ CG FO1
LabNetwork Molecule IDLN01050756
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分类

  • {SNA} Additional Drugs, Analytical Standards, Pharmaceuticals, Illicit Drugs & Alcohol, 分析/色谱
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards L - M, Pharmaceutical Standards, Pharmacopeia Standards
  • Pharmaceuticals
  • Amines
  • {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards L - M, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
  • Intermediates & Fine Chemicals
  • Aromatics

产品应用

  • Dopamine D2 receptor antagonist. Antiemetic.

相关文献及参考

  • Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009),
  • Todorov, S., et al.: Food Technol. Biotechnol., 47, 178 (2009),
  • Dudhane, N., et al.: J. Pharm. Sci. Res., 2, 48 (2010),

安全信息

Hazard Codes Xn
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R64 May cause harm to breast-fed babies 可能导致伤害脯乳期婴儿
GHS Symbol
Precautionary statements
  • P263 Avoid contact during pregnancy/while nursing. 怀孕/哺乳期间避免接触。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P301+P312+P330
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H362 May cause harm to breast-fed children 可能对母乳喂养的婴儿造成伤害
WGK Germany3
Signal word Warning
RTECSBZ3300000
Storage condition 0-10 储存温度2-8℃ 0-10°C
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 3600 ug/kg/6D-I
TOXIC EFFECTS :
   Behavioral - tremor
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   AIMEAS Annals of Internal Medicine.  (American College of Physicians, 4200
   Pine St., Philadelphia, PA 19104)  V.1-    1927-  Volume(issue)/page/year:
   97,621,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   115,649,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 632 mg/kg/59D-I
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - toxic psychosis
   Behavioral - excitement
REFERENCE :
   JCLPDE Journal of Clinical Psychiatry.  (Physicians Postgraduate Press,
   Inc., POB 240008, Memphis, TN 38124)  V.39-    1978-
   Volume(issue)/page/year: 48,38,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 111 mg/kg/37W-I
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - fasciculations
REFERENCE :
   JJMDAT Japanese Journal of Medicine.  (Nankodo Co., Ltd., POB 5272, Tokyo
   International 100-31, Japan)  V.1-30, 1962-1991.  For publisher information,
   see IEDIEP.  Volume(issue)/page/year: 23,152,1984

TYPE OF TEST            : LD50

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 100 nmol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 12,1613,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE                    : 34 mg/kg
SEX/DURATION            : male 60 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - impotence
REFERENCE :
   WJMDA2 Western Journal of Medicine.  (44 Gough St., San Francisco, CA 94103)
    V.120-    1974-  Volume(issue)/page/year: 144,359,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1155 mg/kg
SEX/DURATION            : female 33 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 30,231,1975

其他信息

  • 用途二:镇吐药。本品抑制延脑催吐化学三受区的多巴胺受体。具有强大的中枢镇压吐作用,较氯丙嗪强。本品仅对药物、尿毒症和放射治疗等引起的呕吐有效。
  • 可燃性危险特性:可燃;燃烧产生有毒氮氧化物和氯化物烟雾
  • 储运特性:库房通风低温干燥
  • 毒性分级:高毒
  • 用途一:用作镇吐药
  • MOL 文件:364-62-5.mol
  • 急性毒性:口服-大鼠LD50:750 毫克/公斤; 口服-小鼠LD50:270毫克/公斤
  • 上游原料:氯化胺 --> 邻羟基对氨基苯甲酸甲酯
  • 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
  • 方法一:对氨基水杨酸甲酯(见02220)经酰化、醚化、氯化、胺化、水解得到灭吐灵盐基,再与氯化氢成盐得到灭吐灵(盐酸盐)。
  • 类别:有毒物品

系列性分类


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