1-Indancarboxylic acid, 6-chloro-5-cyclohexyl-, (+-)-

CAS 28968-07-2 MFCD00242786

化学结构图

28968-07-2
SMILES: OC(=O)C1CCC2C=C(C3CCCCC3)C(Cl)=CC=21

化学属性

Mol. FormulaC16H19ClO2
Mol. Weight278.80

别名和识别编码

Chemical Name1-Indancarboxylic acid, 6-chloro-5-cyclohexyl-, (+-)-
Wiswesser Line NotationL56T&J BVQ HG G- AL6TJ -+-
Synonym (+-)-TAI 284 (+-)-6-Chloro-5-cyclohexylindan-1-carboxylic acid (+-)-6-Chloro-5-cyclohexyl-1-indancarboxylic acid 1H-Indene-1-carboxylic acid, 2,3-dihydro-6-chloro-5-cyclohexyl-, (+-) 1H-Indene-1-carboxylic acid, 6-chloro-5-cyclohexyl-2,3-dihydro-, (+-)- TAI-284 dl-TAI 284 (+-)-2,3-Dihydro-6-chloro-5-cyclohexyl-1H-indene-1-carboxylic acid
Beilstein Registry Number2057663
CAS Number28968-07-2
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安全信息

RTECSNK4510000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 7,333,1973

TYPE OF TEST            :

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 41 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 15,1297,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 7,333,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 7,333,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 810 mg/kg
SEX/DURATION            : female 7-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   SEIJBO Senten Ijo.  Congenital Anomalies.  (Nippon Senten Ijo Gakkai, c/o
   Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
   Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
   information, see CGANE7.  Volume(issue)/page/year: 17,177,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 90 mg/kg
SEX/DURATION            : female 7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   SEIJBO Senten Ijo.  Congenital Anomalies.  (Nippon Senten Ijo Gakkai, c/o
   Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
   Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
   information, see CGANE7.  Volume(issue)/page/year: 17,177,1977

系列性分类

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