Methanesulfonanilide,4'-(1-hydroxy-2-(isopropylamino)ethyl)- 索他洛尔

CAS 3930-20-9 MFCD00242936

化学结构图

3930-20-9
SMILES: CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1

化学属性

Mol. FormulaC12H20N2O3S
Mol. Weight272.40
Appearance 白色结晶

别名和识别编码

Chemical NameMethanesulfonanilide,4'-(1-hydroxy-2-(isopropylamino)ethyl)-
Synonym 索他洛尔 Methanesulfonamide, Betacotdone Sotalol (base and/or unspecified salts) Methanesulfonamide, N-(4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)phenyl)- 4'-(1-羟基-2-异丙胺乙基)甲磺酰苯胺 N-(4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl)methanesulfonamide 4'-[1-Hydroxy-2-(isopropylamino)ethyl]metahnesulfonanilide 4'-[1-Hhydroxy-2-(isopropylamino)ethyl]methanesulfonanilide beta-Cardone 索他乐尔 4'-[1-Hydroxy-2-(isopropylamino)ethyl]methanesulfonanilide SOTALOL (RS)-4’-(1-羟基-2-异丙胺基乙基)甲磺酰苯胺 4’-(1-hydroxy-2-(isopropylamino)ethyl)-methanesulfonanilid AURORA KA-855 Methanesulfonanilide, 4'-(1-hydroxy-2-(isopropylamino)ethyl)- DL-4-(2-Isopropylamino-1-hydroxyethyl)methanesulfonanilide n-(4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)phenyl)-methanesulfonamid dl-sotalol SORBITOL 盐酸索他咯尔 Methanesulfonamide, N-[4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]- (9CI) 4’-(1-hydroxy-2-(isopropylamino)ethyl)methanesulfonanilide CAND-1134 N-[4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide
CAS Number3930-20-9
MDL NumberMFCD00242936
Chemical Name Translation索他洛尔
Wiswesser Line NotationWS1&MR DYQ1MY1&1
PubChem Substance ID5253
InChIInChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3
LabNetwork Molecule IDLN01308122
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分类

  • {Chemicalbook} 药物: 拟肾上腺素和抗肾上腺素药: 抗肾上腺素药

安全信息

Hazard Codes Xi
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
RTECSPB0825900 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 3429 ug/kg/2D-I
TOXIC EFFECTS :
   Cardiac - pulse rate increase, without fall in BP
   Cardiac - pulse rate
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ANZJB8 Australian and New Zealand Journal of Medicine.  (Modern Medicine of
   Austr

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 118 mg/kg/4W-I
TOXIC EFFECTS :
   Cardiac - EKG changes not diagnostic of specified effects
   Cardiac - pulse rate
   Cardiac - change in rate
REFERENCE :
   PGMJAO Postgraduate Medical Journal.  (Blackwell Scientific Pub. Ltd., POB
   88, Oxford, UK) V.1-    1925-  Volume(issue)/page/year: 68,289,1992

TYPE OF TEST            : LDLo - Lowest published le

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 113 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #5179095

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 14 mg/kg/3D-I
TOXIC EFFECTS :
   Cardiac - pulse rate increase, without fall in BP
   Cardiac - pulse rate
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   ANZJB8 Australian and New Zealand Journal of Medicine.  (Modern Medicine of
   Australia Pty., Ltd., 100 Pacific Highway, North Sydney, 2060, Australia)
   V.1-    1971-  Volume(issue)/page/year: 24,319,1994

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其他信息

  • MOL 文件:3930-20-9.mol
  • 用途一:降血压药

系列性分类

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