• P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
• P305+P351+P338

• H315 Causes skin irritation 会刺激皮肤
• H319 Causes serious eye irritation 严重刺激眼睛
• H335 May cause respiratory irritation 可能导致呼吸道刺激

• S36 Wear suitable protective clothing 穿戴适当的防护服；
• S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；

• R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Human
DOSE/DURATION           : 150 mg/kg/30D (Continuous)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 206,217,1988

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 mg/L
REFERENCE :
   IDZAAW Japanese Journal of Genetics.  Idengaku Zasshi.  (Genetics Soc. of
   Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan)  V.1-    1921-
   Volume(issue)/page/year: 58,505,1983

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 380 umol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   34,1457,1985

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 ug/plate
REFERENCE :
   BJMRDK Brazilian Journal of Medical and Biological Research.  (Associacao
   Brasileira de Divulg

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Klebsiella pneumoniae
DOSE/DURATION           : 50 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 31,149,1975

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 25 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 230,305,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 8 gm/kg
SEX/DURATION            : male 8 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   COBIEJ Communicaciones Biologicas.  (Communicaciones Biologicas, c/o Dr.
   Amanda Pellegrino de Iraldi, Instituto de Biologia Cellular, Faculated de
   Medicina, Paraguay 2155, Buenos Aires, 1121, Argentina)  V.1-    1982-
   Volume(issue)/page/year: 8,251,1990