Carbutamide 4-氨基-N-(丁基氨基甲酰基)苯磺酰胺

CAS 339-43-5 MFCD00025344

化学结构图

339-43-5
SMILES: CCCCNC(=O)NS(=O)(=O)c1ccc(N)cc1

化学属性

Mol. FormulaC11H17N3O3S
Mol. Weight271

别名和识别编码

Chemical Name4-Amino-N-(Butylcarbamoyl)Benzenesulfonamide
CAS Number339-43-5
Synonym ######## 1-Butyl-3-sulfanilylurea 4-Amino-N-((butylamino)carbonyl)benzenesulfonamide Alentin Aminophenurobutane BZ 55 BZ-55 Benzenesulfonamide, 4-amino-N-((butylamino)carbonyl)- Benzenesulfonamide, 4-amino-N-[(butylamino)carbonyl]- Bucarban Bucrol Bukarban Burcol Butisulfina Butylcarbamide Ca 1022 Carbutamid Carbutamide Cicloral Diabetal Diaboral Emedan Glucidoral Glucofren Glybutamide Inbuton Invenol N'-(4-Aminobenzenesulfonyl)-N-butylurea N'-(4-Aminophenylsulfonyl)-N-butylurea N'-(4-Aminophenylsulfonyl)-N-n-butylurea N'-(Butylcarb
Chemical Name Translation4-氨基-N-(丁基氨基甲酰基)苯磺酰胺
MDL NumberMFCD00025344
Wiswesser Line NotationZR DSWMVM4
Beilstein Registry Number2218915
LabNetwork Molecule IDLN00247437
PubChem Substance ID9564
InChIInChI=1S/C11H17N3O3S/c1-2-3-8-13-11(15)14-18(16,17)10-6-4-9(12)5-7-10/h4-7H,2-3,8,12H2,1H3,(H2,13,14,15)
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分类

  • Amines
  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Sulfur & Selenium Compounds
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; urea; 1fragment

产品应用

  • Antidiabetic.

相关文献及参考

  • Estrada, E., et al.: Bioorg. Med. Chem., 8, 2755 (2000),
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15
  • Short: III/5a Title: Structure Data of Organic Crystals: C ... C 13 Author: Schudt, E.; Weitz, G. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: III/5a Year: 1971 ISBN: 3-540-05177-5 ISBN: 978-3-540-05177-0 Internet Resource: DOI:10.1007/b19970 RefComment: XXI, 736 pages, and VII, 890 pages. Hardcover Abstract: Volume III/5 offers a compitation as complete as possible of the space groups and lattice con-stants of all crystals which have been studied by means of X-rays, neutron and electron diffraction.

安全信息

RTECSYS4200000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1920 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   DIAEAZ Diabetes.  (American Diabetes Assoc., 2 Park Ave., New York, NY
   10016)  V.1-    1952-  Volume(issue)/page/year: 6,2,1957

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 25,93,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2640 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DIAEAZ Diabetes.  (American Diabetes Assoc., 2 Park Ave., New York, NY
   10016)  V.1-    1952-  Volume(issue)/page/year: 6,2,1957

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 25,93,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUT

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 gm/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 28,616,1965

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 12 gm/kg
SEX/DURATION            : female 1-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
   BANMAC Bulletin de l'Academie Nationale de Medicine (Paris).  (Imprimeries
   Reunies de Chambray, 226, route d'Apremont, F-73490 La Ravoire, France) V.1-
      1836-  Volume(issue)/page/year: 143,238,1959

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 4400 mg/kg
SEX/DURATION            : fema

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 4400 mg/kg
SEX/DURATION            : female 5-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - body wall
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   BSVMA8 Bulletin de la Societe des Sciences Veterinaires et de Medecine
   Comparee de Lyon.  (Lyons, France)  V.1-83, 1898-1981.
   Volume(issu

Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P317
  • P337+P317
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

系列性分类

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