2-Methylmalonic acid 2-甲基丙二酸

CAS 516-05-2 MFCD00002656

化学结构图

516-05-2
SMILES: CC(C(=O)O)C(=O)O

化学属性

Mol. FormulaC4H6O4
Mol. Weight118
Density1.45
Melting Point129
Solubility可溶
Appearance 白色结晶。

别名和识别编码

Chemical Name2-Methylmalonic acid
CAS Number516-05-2
Synonym Propanedioic acid, methyl- Malonic acid, methyl- METHYLPROPANEDIOIC ACID 甲基马来酸 2-Methylpropanedioic acid 1,1-ethanedicarboxylicacid Methylmalonic Isosuccinic Acid
EC Number208-219-5
Beilstein Registry Number1756084
MDL NumberMFCD00002656
PubChem Substance ID487
Reaxys-RN1756084
Chemical Name Translation2-甲基丙二酸
Wiswesser Line NotationQV1VO1
LabNetwork Molecule IDLN00009542
InChIInChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8)
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分类

  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {SNA} Building Blocks, C1 to C5, Carbonyl Compounds, Carboxylic Acids, Chemical Synthesis, Organic Building Blocks
  • Aliphatics
  • {uni_hamburg} no charge; carboxylic acid; 1fragment
  • Metabolites & Impurities

产品应用

  • Binds with coenzyme A to form methylmalonyl-CoA, also a metabolic intermediate transformed to succinic acid (SA) by a vitamin B12-dependent catalytic step, and is broadly used as a clinical biomarker

相关文献及参考

  • Pedersen, T., et al.: J. Chromatogr., B: Anal. Technol. Biomed. Life Sci., 879, 1502 (2011),
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15
  • Short: III/10a Title: Structure Data of Organic Crystals: C ... C 15 Author: Schudt-Weitz, G.; Strell, I. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: III/10a Year: 1985 ISBN: 3-540-07834-7 ISBN: 978-3-540-07834-0 Internet Resource: DOI:10.1007/b19984 RefComment: XXII, 634 pages. Hardcover Abstract: The volume includes an alphabetical index of all substances and a separate "ring index" with all cyclic compounds.
  • [1]. Vashi P, et al. Methylmalonic Acid and Homocysteine as Indicators of Vitamin B-12 Deficiency in Cancer.

安全信息

Signal word
GHS Symbol
WGK Germany3
Safety Statements
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P332+P313
  • P305+P351+P338+P337+P313
RTECSOO1400000
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CBCCT* "Summary Tables of Biological Tests," National Research Council
   Chemical-Biological Coordination Center.  (National Academy of Science
   Library, 2101 Constitution Ave., NW, Washington, DC 20418)
   Volume(issue)/page/year: 6,222,1954

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#02314

其他信息

  • 用途一:用于有机合成
  • 甲基丙二酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M0568 甲基丙二酸 Methylmalonic Acid 100G 2180元 2014/06/02 M0568 甲基丙二酸 Methylmalonic Acid 10G 458元 2014/06/02 M0568 甲基丙二酸 Methylmalonic Acid 25G 846元
  • MSDS 信息:2-Methylpropanedioic acid(516-05-2).msds
  • 图谱信息:甲基丙二酸(516-05-2)核磁图( 1 HNMR) 甲基丙二酸(516-05-2)质谱(MS) 甲基丙二酸(516-05-2)红外图谱(IR2) 甲基丙二酸(516-05-2)核磁图( 13 CNMR) 甲基丙二酸(516-05-2)红外图谱(IR1)
  • TCI Shanghai:甲基丙二酸 Methylmalonic Acid,>;98.0%(T)(516-05-2)
  • 下游产品:兔耳草醛
  • Sigma Aldrich:516-05-2(sigmaaldrich)
  • MOL 文件:516-05-2.mol
  • Acros Organics:甲基丙二酸 Methylmalonic acid, 96%(516-05-2)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Organic Acids - Synthetic Reagents
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids - Carbonyl Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids - Carbonyl Compounds
  6. C1 to C5 - Carboxylic Acids
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids - Carbonyl Compounds
  6. C1 to C5 - Carboxylic Acids
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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