2-Fluoroethanol 2-氟乙醇

CAS 371-62-0 MFCD00002828

化学结构图

371-62-0
SMILES: OCCF

化学属性

Mol. FormulaC2H5FO
Mol. Weight64
Boiling Point103
TSCAT
Melting Point-26.5
Density1.091
Refractive index1.3650
Flash Point31°(87°F)
Vapor Pressure16 mmHg ( 20 °C)
Appearance 带有醇气味的无色液体。 与水和许多有机溶剂互溶。
Solubility与水和许多有机溶剂互溶

别名和识别编码

Chemical Name2-Fluoroethanol
CAS Number371-62-0
Alfabeta NameFLUOROETHANOL 2-
MDL NumberMFCD00002828
Synonym 2-Fluoro-1-ethanol 2-Fluoro-1-ethanol; Ethylene fluorohydrin 2-Fluoroethylalcohol 2-fluoro-ethanol 2-fluoroethanol 2-fluoroethanol, sodium salt Ethanol, 2-fluoro- Ethylene fluorhydrin Ethylene fluorohydrin: (2-Fluoroethanol) MONOFLUOROETHANOL TL 741 ethanol, 2-fluoro- fluoroethanol
EC Number206-740-2
Beilstein Registry Number1730857
PubChem Substance ID9737
Chemical Name Translation2-氟乙醇
Wiswesser Line NotationQ2F
LabNetwork Molecule IDLN00118193
InChIInChI=1S/C2H5FO/c3-1-2-4/h4H,1-2H2
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分类

  • {uni_hamburg} no charge; alcohol; 1fragment
  • {SNA} Alcohols, Alkyl Fluorinated Building Blocks, Building Blocks, C2 to C6, Chemical Synthesis, Fluorinated Building Blocks, Organic Building Blocks, Organic Fluorinated Building Blocks, Other Fluorinated Organic Building Blocks, Oxygen Compounds

产品应用

  • 抗菌药物氟罗沙星(fleroxacin)的中间体。

相关文献及参考

  • Short: II/25B
  • Beilstein: 1,IV,1366
  • Short: II/24B

安全信息

Warnings TOXIC BY INHALATION, FLAMMABLE
RTECSKL1575000
Packing GroupI
UN Number 3383 UN 3383 6.1/PG 1
Risk Statements
  • R10 Flammable 易燃
  • R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有剧毒
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Storage condition Air Sensitive
GHS Symbol
WGK Germany3
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H300 Fatal if swallowed 吞食致命
  • H310 Fatal in contact with skin 皮肤接触致命
  • H330 Fatal if inhaled 吸入致命
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P242 Use only non-sparking tools. 只能使用无火花工具。
  • P243 Take precautionary measures against static discharge. 采取预防措施,防止静电放电。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P310
  • P302+P350
  • P303+P361+P353
  • P304+P340
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P320 Specific treatment is urgent (see … on this label). 紧急具体治疗(见本标签上的)。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P370+P378
  • P403+P233
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Hazard Codes 6.1 T+ T+,T,F
Hazard Class6.1
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 35 mg/m3/10M
TOXIC EFFECTS :
   Behavioral - coma
   Lungs, Thorax, or Respiration - respiratory stimulation
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB158-508

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,515,1986

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUT

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 25 mg/m3/10M
TOXIC EFFECTS :
   Behavioral - coma
   Lungs, Thorax, or Respiration - respiratory stimulation
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB158-508

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 150 mg/m3/10M
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :

其他信息

  • 蒸气压:16 mm Hg ( 20 °C)
  • 防护措施:毒性较大,小鼠腹腔注射LD50为60mg/kg。生产设备应密闭,进行负压操作。车间应有良好通风。操作人员应穿戴防护用具。
  • 上游原料:乙二醇 --> 2-氯乙醇
  • 敏感性:Air Sensitive
  • 方法一:将2-氯乙醇96.6g(1.2mol)滴加到94ml乙二醇和105g(1.8mol)无水氟化钾的混合物中,在180℃保温反应2h,得2-氟乙醇32.34g,收率42.1%。
  • 常规方法:产品应装入棕色玻璃瓶内,外套木箱包装。
  • 性质稳定,蒸馏时不分解,与水和许多有机溶剂互溶。
  • 下游产品:对甲苯磺酸氟乙酯
  • 2-氟乙醇价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/05/25 L01735 2-氟乙醇, 95% 2-Fluoroethanol, 95% 5g 605元 2010/05/25 L01735 2-氟乙醇, 95% 2-Fluoroethanol, 95% 25g 1876元 2010/05/25 L01735 2-氟乙醇, 95% 2-Fluoroethanol, 95% 1g 190元
  • MOL 文件:371-62-0.mol
  • MSDS 信息:Ethylene fluorohydrin(371-62-0).msds
  • Sigma Aldrich:371-62-0(sigmaaldrich)
  • Alfa Aesar:2-氟乙醇,95% 2-Fluoroethanol, 95%(371-62-0)
  • TSCA:T
  • 用途二:抗菌药物氟罗沙星(fleroxacin)的中间体。2-氟乙醇及其衍生物用于毒杀啮齿动物,其衍生物可作除草剂及毒杀一些植物害虫。
  • 用途一:用作医药、农药中间体

系列性分类


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