8-Bromoguanosine 3',5'-cyclic monophosphate sodium salt 8-溴代鸟苷-3',5'-环状单磷酸酯钠盐

CAS 51116-01-9 MFCD00070128

化学结构图

51116-01-9
SMILES: [Na+].NC1NC(=O)C2N=C(Br)N([C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)C=2N=1

化学属性

Mol. FormulaC10H10BrN5NaO7P
Mol. Weight446

别名和识别编码

Chemical Name8-Bromoguanosine 3',5'-cyclic monophosphate sodium salt
Synonym 8-Br-cGMP 8-Br-cGMP 8-Bromo-cyclic GMP 8-Bromo-cyclic GMP 8-Bromoguanosine-3',5'-cyclomonophosphate sodium salt
MDL NumberMFCD00070128
PubChem Substance ID24278021
CAS Number51116-01-9
EC Number256-993-8
Beilstein Registry Number8378760
Chemical Name Translation8-溴代鸟苷-3',5'-环状单磷酸酯钠盐
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分类

  • {SNA} Biochemicals and Reagents, Nucleoside Analogs, Nucleosides, Nucleotides, Oligonucleotides
  • B, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, Cyclic Nucleotides and Analogs, G Proteins and Cyclic Nucleotides, Kinase/Phosphatase Biology, Protein Kinase G (PKG),

相关文献及参考

  • Choi, J., and Farley, J.M., Effects of 8-bromo-cyclic GMP on membrane potential of single swine tracheal smooth muscle cells. J. Pharmacol. Exp. Ther. 285 , 588-594, (1998) 摘要
  • Francis, S.H., et al., Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase. Mol. Pharmacol. 34 , 506-517, (1988) 摘要
  • Garg, U.C., and Hassid, A., Inhibition of rat mesangial cell mitogenesis by nitric oxide-generating vasodilators. Am. J. Physiol. 257 , F60-F66, (1989) 摘要
  • Garg, U.C., and Hassid, A., Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J. Clin. Invest. 83 , 1774-1777, (1989) 摘要
  • Prakash, Y.S., et al., Nitric oxide inhibits ACh-induced intracellular calcium oscillations in porcine tracheal smooth muscle. Am. J. Physiol. 272 , L588-L596, (1997) 摘要
  • Ruth, P., et al., The activation of expressed cGMP-dependent protein kinase isozymes Iα and Iβ is determined by the different amino-termini. Eur. J. Biochem. 202 , 1339, (1991) 摘要

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
GHS Symbol
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。

系列性分类


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