(R)-1-Methyl-3-pyrrolidinol (R)-(-)-1-甲基-3-羟基吡咯烷

CAS 104641-60-3 MFCD03788747

化学结构图

104641-60-3
SMILES: CN1C[C@@H](O)CC1 |&1:3|

化学属性

Mol. FormulaC5H11NO
Mol. Weight101
Refractive index1.4630 to 1.4670
Boiling Point50-52
Density0.921
Flash Point71°C(lit.)
TSCANo

别名和识别编码

Chemical Name(R)-1-Methyl-3-pyrrolidinol
CAS Number104641-60-3
Alfabeta NameHYDROXYMETHYLPYRROLIDINE R31()----
MDL NumberMFCD03788747
Synonym (R)-(-)-3-羟基-N-甲基吡咯烷 (3R)-1-Methylpyrrolidin-3-ol (R)-(-)-1-Methyl-3-pyrrolidinol (3R)-1-Methylpyrrolidin-3-ol (R)-(-)-3-羟基-N-甲基吡咯烷 (R)-N-Methyl-3-pyrrolidinol (R)-(-)-1-甲基-3-吡咯烷醇 (R)-N-Methyl-3-pyrrolidinol
PubChem Substance ID87560086
EC Number000-000-0
Beilstein Registry Number4349393
Chemical Name Translation(R)-(-)-1-甲基-3-羟基吡咯烷
Reaxys-RN4349393
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分类

  • {SNA} Asymmetric Synthesis, Chemical Synthesis, Chiral Building Blocks, Heterocyclic Building Blocks, Pyrrolidines
  • {SA} Asymmetric Synthesis, Chemical Synthesis, Chiral Building Blocks, Heterocyclic Building Blocks, Pyrrolidines

相关文献及参考

  • 1. Isakovic, L.; et al., Constrained (-)-S-adenosyl-L-homocysteine (SAH) analogues as DNA methyltransferase inhibitors Bioorg. Med. Chem. Lett. 19 , 2742-2746, (2009)
  • 2. Moorjani, M.; et al., 2,6-Diaryl-4-acylaminopyrimidines as potent and selective adenosine A2A antagonists with improved solubility and metabolic stability Bioorg. Med. Chem. Lett. 18 , 5402-5405, (2008)
  • 3. Gobbini, M.; et al., Novel Analogues of Istaroxime, a Potent Inhibitor of Na + ,K + -ATPase: Synthesis and Structure-Activity Relationship J. Med. Chem. 51 , 4601-4608, (2008)
  • 4. Wu, W.-M.; et al., Stereoisomers of N-substituted soft anticholinergics and their zwitterionic metabolite based on glycopyrrolate - syntheses and pharmacological evaluations Pharmazie 63 , 200-209, (2008)
  • Product of Toray Industries, Inc.

安全信息

Warnings IRRITANT
GHS Symbol
WGK Germany3
Hazard Codes Xi
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H227 Combustible liquid 可燃液体
Personal Protective Equipment Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P370+P378
  • P305+P351+P338+P337+P313
Signal word
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Storage condition Air Sensitive & Hygroscopic 0-10°C

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrrolidines 吡咯烷
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Building Blocks 手性分子砌块
  4. Heterocyclic Building Blocks - Chiral Building Blocks
  5. Pyrrolidines - Heterocyclic Building Blocks

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