2-Propylisonicotinylthioamide 丙硫异烟胺

CAS 14222-60-7 MFCD00464119

化学结构图

14222-60-7
SMILES: CCCC1=CC(=CC=N1)C(N)=S

化学属性

Mol. FormulaC9H12N2S
Mol. Weight180
Melting Point141.0 to 145.0 deg-C

别名和识别编码

Chemical Name2-Propylisonicotinylthioamide
CAS Number14222-60-7
Alfabeta NamePROPYLPYRIDINECARBOTHIOAMIDE 24---
MDL NumberMFCD00464119
Synonym Trevintix 2-Propyl-4-thiocarbamoylpyridine Prothionamide Protionamid prothionamide TH 1321 Tebeform protionamide (INN) Trevi RP 9778 2-Propyl-4-thiocarbamoyl pyridine 2-Propyl-thioisonicotinamide Tuberex Protionizina Ektebin Peteha 2-Propyl-4-pyridinecarbothioamide 2-propyl(thioisonicotinamide) 2-Propylthioisonicotinamide 1321 TH 2-Propylisonicotinylthioamide 9778 R.P. protionamide Protion 9778 R. P. Protionamide 4-Pyridinecarbothioamide, 2-propyl-
EC Number238-093-7
Chemical Name Translation丙硫异烟胺
Beilstein Registry Number0118164
LabNetwork Molecule IDLN00160920
Reaxys-RN118164
Merck Number7891
PubChem Substance ID253660961
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分类

  • Amines
  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Sulfur & Selenium Compounds
  • {uni_hamburg} no charge; nitrogen heterocycle; aromatic; 6RingOnly; 6ring; 1fragment

产品应用

  • An anti-tuberculosis agent. It has also been used to treat Leprosy. Antibacterial (tuberculostatic).

相关文献及参考

  • Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),
  • van Ingen, J., et al.: Int. J. Antimicrob. Agents, 35, 169 (2010),
  • Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010),
  • Short: III/10a Title: Structure Data of Organic Crystals: C ... C 15 Author: Schudt-Weitz, G.; Strell, I. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: III/10a Year: 1985 ISBN: 3-540-07834-7 ISBN: 978-3-540-07834-0 Internet Resource: DOI:10.1007/b19984 RefComment: XXII, 634 pages. Hardcover Abstract: The volume includes an alphabetical index of all substances and a separate "ring index" with all cyclic compounds.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

Warnings IRRITANT
RTECSNS0650000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 660 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,726,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - muscle weakness
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 38,471,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 760 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,726,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1320 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - muscle weakness
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(is

Hazard statements
  • H302 Harmful if swallowed 吞食有害
GHS Symbol
Signal word
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338+P337+P313
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyridines 吡啶

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