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分类

• {SNA} A-AM, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antitumor Agents, Apoptosis Inducers, Apoptosis and Cell Cycle, Benzenoids, Bioactive Small Molecules, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Chemical Structure Class, HSP-90 Inhibitors, Inhibits an Enzyme, Mechanism of Action
• Inhibitors
• Heterocycles
• Pharmaceuticals
• Intermediates & Fine Chemicals
• Amines
• {SNA} A-AM, Antibiotics A to Z, Antibiotics A-F, Antitumor Agents, Apoptosis Inducers, Apoptosis and Cell Cycle, Benzenoids, Bioactive Small Molecule Alphabetical Index,

产品应用

• Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic prote

相关文献及参考

• [2]. Raja, Srikumar M., et al. 17-AAG induces enhanced ubiquitinylation and lysosomal pathway-dependent ErbB2 degradation and cytotoxicity in ErbB2-overexpressing breast cancer cells. Cancer Biology & Therapy (2008), 7(10), 163
• [3]. Zhang J, et al. The heat shock protein 90 inhibitor 17-AAG suppresses growth and induces apoptosis in human cholangiocarcinoma cells.Clin Exp Med. 2012 Sep 7.
• [4]. Newman B, et al. HSP90 Inhibitor 17-AAG Selectively Eradicates Lymphoma Stem Cells.Cancer Res. 2012 Sep 1;72(17):4551-61. Epub 2012 Jun 29.
• [5]. Kamal A, et al. A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature. 2003 Sep 25;425(6956):407-10.
• [6]. Enomoto A, et al. The HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin modulates radiosensitivity by downregulating serine/threonine kinase 38 via Sp1 inhibition. Eur J Cancer. 2013 Nov;49(16):3547-58.
• Basso, A.D., et al.: Oncogene, 21, 1159 (2002),
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