2-Methyl-2-Thiazoline 2-甲基-2-噻唑啉

CAS 2346-00-1 MFCD00005314

化学结构图

2346-00-1
SMILES: CC1=NCCS1

化学属性

Mol. FormulaC4H7NS
Mol. Weight101.17
Refractive index1.5170 to 1.5210
Boiling Point145.0±0.0°C at 760 mmHg
Density1.067 g/mL at 25 °C(lit.)
Melting Point-101.0 °C
Flash Point37°C(lit.)
TSCAYes

别名和识别编码

Chemical Name2-Methyl-2-Thiazoline
MDL NumberMFCD00005314
CAS Number2346-00-1
PubChem Substance ID87572362
EC Number219-071-6
Beilstein Registry Number27,13
Synonym 2-Methyl-4,5-dihydrothiazole {LY} 2-Methyl-4,5-dihydrothiazole {} {LY} 2-Methyl-4,5-dihydrothiazole {} {} {LY} 2-Methyl-4,5-dihydrothiazole {} {} {} {LY} 2-Methyl-4,5-dihydrothiazole {} {} {} {} {LY} 2-Methyl-4,5-dihydrothiazole {} {} {} {} {} {LY} 2-Methyl-4,5-dihydrothiazole {} {} {} {} {} {} {LY} 2-Methyl-4,5-dihydrothiazole {} {} {} {} {} {} {} {LY} 2-Methyl-4,5-dihydrothiazole {} {} {} {} {} {} {} {} {LY} 2-Methyl-4,5-dihydrothiazole {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {LY} 2-Methyl-4,5-dihydrothiazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Methyl-4,5-dihydrothiazole {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Methyl-4,5-dihydrothiazole {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Methyl-4,5-dihydrothiazole {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Methyl-4,5-dihydrothiazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Methyl-4,5-dihydrothiazole {} {} {} {} {} {} {}
Reaxys-RN104274
Chemical Name Translation2-甲基-2-噻唑啉
LabNetwork Molecule IDLN00224994
InChIInChI=1S/C4H7NS/c1-4-5-2-3-6-4/h2-3H2,1H3
Canonical SMILESCC1=NCCS1
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分类

  • {SNA} Alphabetical Listings, Flavors and Fragrances, M-N
  • {SNA} Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, Thiazolines/Thiazolidines

产品应用

  • 医药中间体。

相关文献及参考

  • Acetaldehyde anion synthon, by metallation at the methyl group. ɑ-Mono-, di- and trisubstituted aldehydes can be prepared by successive lithiation and alkylation steps. The anion also reacts, e.g.with carbonyl groups to give precursors of ß-hydroxy aldehydes. The thiazoline residue can be removed by reduction with Al amalgam and treatment with HgCl2: J. Org. Chem., 40, 2021, 2025 (1975). Compare Thiazole, L09970, 2-Bromothiazole, A14838, and 2-(Trimethyl­silyl)­thiazole, B21903.
  • Beilstein:27,13

安全信息

GHS Symbol
WGK Germany2
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSXJ4261470
Signal word Warning
Packing GroupIII
UN Number 1993 UN 1993 3/PG 3 UN1993
Risk Statements
  • R10 Flammable 易燃
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P303+P361+P353
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P370+P378
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P403+P235
  • P241+P242+P243
  • P233 Keep container tightly closed. ?保持容器密闭。
Storage condition 2-8°C, protect from light, stored under nitrogen {LY} 2-8°C, protect from light, stored under nitrogen {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitr
Hazard Class3
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 480 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 24(1),55,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 24(1),55,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
   (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
   V.9-    1974-  Volume(issue)/page/year: 20,16,1985

其他信息

  • 图谱信息:2-甲基-2-噻唑啉(2346-00-1)红外图谱(IR1) 2-甲基-2-噻唑啉(2346-00-1)核磁图( 13 CNMR) 2-甲基-2-噻唑啉(2346-00-1)质谱(MS)
  • MSDS 信息:2-Methyl-2-thiazoline(2346-00-1).msds
  • 上游原料:甲苯 --> 三乙胺 --> 乙酰氯 --> 乙醇胺 --> 五硫化二磷
  • Sigma Aldrich:2346-00-1(sigmaaldrich)
  • 用途一:用作增感染料中间体
  • Alfa Aesar:2-甲基噻唑啉,97% 2-Methyl-2-thiazoline, 97%(2346-00-1)
  • 海关编码:29341000
  • TCI Shanghai:2-甲基噻唑啉 2-Methylthiazoline,>;97.0%(GC)(2346-00-1)
  • 用途二:医药中间体。
  • F:8-10-23
  • MOL 文件:2346-00-1.mol
  • 2-甲基-2-噻唑啉价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M0285 2-甲基噻唑啉 2-Methylthiazoline 25ML 558元 2014/06/02 M0285 2-甲基噻唑啉 2-Methylthiazoline 100ML 1670元 2010/05/25 L01329 2-甲基噻唑啉, 97% 2-Methyl-2-thiazoline, 97% 25g 507元

系列性分类

  1. Application Areas 应用领域分类
  2. Flavors and Fragrances 香精香料
  3. Alphabetical Listings - Flavors and Fragrances
  4. M-N - Alphabetical Listings
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Thiazoles 噻唑
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Thiazolines/Thiazolidines 噻唑啉/噻唑烷
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Thiazolines/Thiazolidines 噻唑啉/噻唑烷
  1. Functional Group 官能团索引
  2. imidothioester

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