Apocodeine hydrochloride

CAS 6377-14-6 MFCD00055171

化学结构图

6377-14-6
SMILES: COc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3.Cl

化学属性

Mol. FormulaC18H19NO2.ClH
Mol. Weight317.84

别名和识别编码

Chemical NameApocodeine hydrochloride
CAS Number6377-14-6
Synonym Apocodeine hydrochloride (6aR)-5,6,6a,7-Tetrahydro-10-methoxy-6-methyl-4H-dibenzo[de,g]quinolin-11-ol Hydrochloride R(-)-10-Methoxy-11-hydroxyaporphine hydrochloride 10-Methoxy-6a?-aporphin-11-ol Monohydrochloride NSC 305238 10-Methoxy-6a-beta-aporphin-11-ol hydrochloride
MDL NumberMFCD00055171
PubChem Substance ID11957528
InChIKeyNIWCFXFECXNXGD-PFEQFJNWSA-N
Wiswesser Line NotationT C6666 1A Q KN&TT&J DQ EO1 K1 &GH
InChIInChI=1S/C18H19NO2.ClH/c1-19-9-8-11-4-3-5-13-16(11)14(19)10-12-6-7-15(21-2)18(20)17(12)13;/h3-7,14,20H,8-10H2,1-2H3;1H/t14-;/m1./s1
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分类

  • Chiral Reagents
  • Heterocycles
  • Metabolites & Impurities
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {SA} AN-AZ, Agonists, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Dopaminergics, Neuroscience, Neurotransmission, Neurotransmitters

产品应用

  • A metabolite of Apomorphine (A727500). Dopamine receptor agonist. Emetic.

相关文献及参考

  • Neumeyer, et al.: J. Med. Chem., 16, 1223 (1973),

安全信息

RTECSCE1055000
WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 128 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 11,977,1968

系列性分类

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