Beclomethasone 17-Monopropionate 倍氯米松17-丙酸酯

CAS 5534-18-9 MFCD05534189

化学结构图

5534-18-9
SMILES: CCC(=O)O[C@]1(C(=O)CO)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3(Cl)[C@@H](O)C[C@@]21C

化学属性

Mol. Weight464.98
Mol. FormulaC25H33ClO6
Melting Point124-126 °C
Boiling Point608.9±55.0 °C at 760 mmHg

别名和识别编码

CAS Number5534-18-9
Chemical NameBeclomethasone 17-monopropionate
Synonym Beclomethasone 17-propionate {LY} Beclomethasone 17-propionate beclomethasone 17-monopropionate beclomethasone 17-propionate {} {LY} Beclomethasone 17-propionate {} {} {LY} Beclomethasone 17-propionate {} {} {} {LY} Beclomethasone 17-propionate {} {} {} {} {LY} Beclomethasone 17-propionate {} {} {} {} {} {LY} Beclomethasone 17-propionate {} {} {} {} {} {} {LY} Beclomethasone 17-propionate {} {} {} {} {} {} {} {LY} Beclomethasone 17-propionate {} {} {} {} {} {} {} {} {LY} Beclomethasone 17-propionate {} {} {} {} {} {} {} {} {} {LY} Beclomethasone 17-propionate {} {} {} {} {} {} {} {} {} {} {LY} Beclomethasone 17-propionate {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} Beclomethasone 17-propionate {} {} {} {} {} {} {} {} {} {} {} {} {LY} Beclomethasone 17-propionate {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Beclomethasone 17-propionate {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {}
EC Number226-888-1
Chemical Name Translation倍氯米松17-丙酸酯
LabNetwork Molecule IDLN01274417
PubChem Substance ID62965
InChIInChI=1S/C25H33ClO6/c1-5-21(31)32-25(20(30)13-27)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,26)19(29)12-23(18,25)4/h8-9,11,14,17-19,27,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1
Canonical SMILESC[C@@]12[C@](C(CO)=O)(OC(CC)=O)[C@@H](C)C[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C2)=O
MDL NumberMFCD00870754
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分类

  • Metabolites & Impurities
  • Steroids,

产品应用

  • Active

相关文献及参考

  • [2]. Roberts JK, et al. Metabolism of beclomethasone dipropionate by cytochrome P450 3A enzymes. J Pharmacol Exp Ther. 2013 May;345(2):308-16.
  • [3]. Plumb J, et al. Evaluation of glucocorticoid receptor function in COPD lung macrophages using beclomethasone-17-monopropionate. PLoS One. 2013 May 21;8(5):e64257.
  • Soria, I., et al.: Biopharm. Drug Dispos., 19, 297 (1998),
  • [1]. Würthwein G, et al. Activation of beclomethasone dipropionate by hydrolysis to beclomethasone-17-monopropionate. Biopharm Drug Dispos. 1990 Jul;11(5):381-94.
  • [1]. Würthwein G, et al. Activation of beclomethasone dipropionate by hydrolysis to beclomethasone-17-monopropionate. Biopharm Drug Dispos. 1990 Jul;11(5):381-94.
  • [2]. Roberts JK, et al. Metabolism of beclomethasone dipropionate by cytochrome P450 3A enzymes. J Pharmacol Exp Ther. 2013 May;345(2):308-16.
  • [3]. Plumb J, et al. Evaluation of glucocorticoid receptor function in COPD lung macrophages using becl

安全信息

GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P203
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P312
  • P301+P317
  • P308+P313
  • P318
  • P330 Rinse mouth. 漱口
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Storage condition -20°C, stored under nitrogen {LY} -20°C, stored under nitrogen {} {LY} -20°C, stored under nitrogen {} {} {LY} -20°C, stored under nitrogen {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Glucocorticoid Receptor  (糖皮质激素受体)
  1. Medical Research Areas
  2. Metabolism
  3. Drug Metabolite  (药物代谢物)

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