TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#00697

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 5357 ug/kg
TOXIC EFFECTS :
   Autonomic Nervous System - sympathomimetic
   Vascular - BP elevation not characterized in autonomic section
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 34,205,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 270 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   APPFAR Acta Poloniae Pharmaceutica (English Translation).  Translation of
   APPHAX.  (Warsaw, Poland) V.20-29, 1963-72.  Discontinued.
   Volume(issue)/page/year: 26,598,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 260 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   APPFAR Acta Poloniae Pharmaceutica (English Translation).  Translation of
   APPHAX.  (Warsaw, Poland) V.20-29, 1963-7

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 300 mg/kg/5D (Continuous)
REFERENCE :
   40QBA3 "Proceedings of the International Congress on Toxicology, Toxicology
   as a Predictive Science, 1st, Toronto, 1977," Plaa, G.L., and W.A. Duncan,
   eds., New York, Academic Press, Inc., 1978  Volume(issue)/page/year:
   -,459,1978

TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 300 mg/kg/5D (Continuous)
REFERENCE :
   40QBA3 "Proceedings of the International Congress on Toxicology, Toxicology
   as a Predictive Science, 1st, Toronto, 1977," Plaa, G.L., and W.A. Duncan,
   eds., New York, Academic Press, Inc., 1978  Volume(issue)/page/year:
   -,459,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 480 mg/kg
SEX/DURATION            : female 10-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - cytological changes (including
   somatic cell genetic material)
   Reproductive - Specific Developmental Abnormalities - immune and
   reticuloendothelial system
REFERENCE :
   VAAZA2 Virchows Archiv, Abteilung B: Cell Pathology.  (Springer-Verlag,
   Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.)  V.1-    1968-
   Volume(issue)/page/year: 12,295,1973