Glutethimide 格鲁米特

CAS 77-21-4 MFCD00056091

化学结构图

77-21-4
SMILES: CCC1(c2ccccc2)CCC(=O)NC1=O

化学属性

Mol. FormulaC13H15NO2
Mol. Weight217.29

别名和识别编码

Chemical NameGlutarimide, 2-ethyl-2-phenyl-
Synonym (R,S)-2,6-piperidinedione, 3-ethyl-3-pheyn (R,S)-3-ethyl-3-phenyl-2,6-piperidinedione (±)-2-Ethy (±)-3-Ethyl-3-phenyl-2,6-piperidinedione (±)-Glutethimide 2,6-Piperidinedione, 3-ethyl-3-phenyl- 2,6-piperidinedione,3-ethyl-3-phenyl 2-Ethyl-2-phenylglutarimide 2-Phenyl-2-ethylglutaric acid imide 2-ethyl-2-phenyl-glutarimid 2-ethyl-2-phenylglutarimide 2-phenyl-2-ethylglutaricacidimide 3-ETHYL-3-PHENYL-2,6-PIPERIDINEDIONE 3-Ethyl- 3-Ethyl-3-pheny 3-Ethyl-3-phenyl-2,6-dioxopiperidine 3-Ethyl-3-phenyl-2,6-piperidinedione 3-Phenyl-3-ethyl-2,6-diketopiperidine 3-Phenyl-3-ethyl-2,6-dioxopiperidine 3-ethyl-3-phenyl-piperidine-2,6-dione 3-乙基-3-苯基-2,6-哌啶二酮 Alfimid Dorid
MDL NumberMFCD00056091
EC Number201-012-0
CAS Number77-21-4
Chemical Name Translation格鲁米特
Wiswesser Line NotationT6VMVTJ D2 DR
PubChem Substance ID3487
InChIInChI=1S/C13H15NO2/c1-2-13(10-6-4-3-5-7-10)9-8-11(15)14-12(13)16/h3-7H,2,8-9H2,1H3,(H,14,15,16)
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分类

  • {uni_hamburg} no charge; nitrogen heterocycle; carbocycle; aromatic; 6RingOnly; 6ring; amide; lactame; racemate; 1fragment
  • {SNA} Alphabetic, Analytical Standards, Analytical/Chromatography, G

相关文献及参考

  • Short: IV/8A Title: Enthalpies of Fusion and Transition of Organic Compounds Author: Zhang, Z.-Y.; Frenkel, M.; March, K.N.; Wilhoit, R.C. Editor: Marsh, K.N. Source: Landolt-Börnstein, New Series Volume: IV/8A Year: 1995 Keyword: organic compounds; enthaly of fusion; melting point; phase transition ISBN: 3-540-58854-X ISBN: 978-3-540-58854-2 Internet Resource: DOI:10.1007/b55145 RefComment: VIII, 588 pages.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H302 Harmful if swallowed 吞食有害
RTECSMA4725000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Packing GroupIII
Hazard Codes Xn
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Hazard Class6.1(b)
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
UN Number 3249
Restrict {} 精神药品 精麻类化学品 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Rectal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOIZAG Toho Igakkai Zasshi.  Journal of Medical Society of Toho University.
   (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
   Japan)  V.1-    1954-  Volume(issue)/page/year: 7,513,1960

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   AJDCAI American Journal of Diseases of Children.  (AMA, 535 N. Dearborn St.,
   Chicago, IL 60610) V.1-80(3), 1911-50; V.100-    1960-
   Volume(issue)/page/year: 130,507,1976

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 147 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M.,
   Springfield, IL, C.C. Thomas, 1970  Volume(issue)/page/year: 2,73,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 171 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - coma
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicag

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2250 mg/kg
SEX/DURATION            : female 6-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   BSAMA5 Bulletin der Schweizerischen Akademie der Medizinischen
   Wissenschaften. (Schwabe & Co., Steinentorstr. 13, CH-4010 Basel,
   Switzerland)  V.1-    1944-  Volume(issue)/page/year: 20,490,1964

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2250 mg/kg
SEX/DURATION            : female 6-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.
   (Paris, France)  V.1-261, 1835-1965.  For publisher information, see CRASEV.
    Volume(issue)/page/year: 256,1841,1963

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 300 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   CAJPBD Proceedings of the Congenital Anomalies Research Association of
   Japan.  (Kyoto, Japan) No.1-    1961-  Volume(issue)/page/year: 3,2,1963

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 1350 mg/kg
SEX/DURATION            : female 8-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system

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Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P312
  • P330 Rinse mouth. 漱口
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

其他信息

  • Sigma Aldrich:77-21-4(sigmaaldrich)
  • MSDS 信息:2-Ethyl-2-phenylglutarimide(77-21-4).msds
  • MOL 文件:77-21-4.mol

系列性分类

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