Bipariden 比哌立登
CAS 514-65-8 MFCD05662335
化学结构图
SMILES: OC(CCN1CCCCC1)(C1C[C@@H]2C[C@H]1C=C2)C1C=CC=CC=1 |&1:12,14|
化学属性
| Mol. Formula | C21H29NO |
|---|---|
| Mol. Weight | 311.51 |
| Melting Point | 114 ºC |
| Solubility | 25.1 MG/L |
别名和识别编码
| Chemical Name | Biperiden |
|---|---|
| Synonym | 5-Norbornene-2-methanol, alpha-phenyl-alpha-(2-piperidinoethyl)- Akineton 3-Piperidino-1-phenyl-1-bicycloheptenyl-1-propanol alpha-(Bicyclo(2.2.1)hept-5-en-2-yl)-alpha-phenyl-1-piperidino propanol 3-Piperidino-1-phenyl-1-bicyclo- alpha-(bicyclo(2.2.1)hept-5-en-2-yl)-alpha-phenyl-1-piperidinopropanol 1-Piperidinepropanol, alpha-bicyclo[2.2.1]hept-5-en-2-yl-alpha-phenyl- α-bicyclo[2.2.1]hept-5-en-2yl-α-phenyl-1-piperidinepropanol 双环哌丙醇 1-Bicycloheptenyl-1-phenyl-3-piperidino-propanol-1 1-Piperidinepropanol, alpha-bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl- alpha-phenyl-alpha-(2-piperidinoethyl)-5-norbornene-2-methano 安克痉 3-哌啶基-1-苯基-双环庚烯基-1-丙醇 碧卜利旦 比哌立登 alpha-bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl-1-piperidinepropano Beperiden 1-(5-双环[2.2.1]庚-2-烯基)-1-苯基-3-(1-哌啶基)丙-1-醇 1-Piperidinepropanol, alpha-5-norbornen-2-yl-alpha-phenyl- alpha-5-norbornen-2-yl-alpha-phenyl-1-piperidinepropano alpha-5-Norbornen-2-yl-alpha-phenyl-1-piperidinepropanol 3-Piperidino-1-phenyl-1-bicyclo(2.2.1)hepten-(5)-yl-propanol-(1) Akinophyl a-bicyclo[2.2.1]hept-5-en-2yl-a-phenyl-1-piperidinepropanol 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidyl)propan-1-ol -5-Norbornen-2-yl-phenyl-1-piperidinepropanol biperiden bipariden 1-(5-Bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidyl)propan-1-ol KL 373 Biperiden 1-Bicyclo[2.2.1]hept-5-en-2-yl-1-phenyl-3-(1-piperidinyl)-1-propanol |
| EC Number | 208-184-6 |
| CAS Number | 514-65-8 |
| Chemical Name Translation | 比哌立登 |
| Wiswesser Line Notation | L55 A CUTJ FXQR&2- AT6NTJ |
| Beilstein Registry Number | 0290038 |
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分类
- {uni_hamburg} no charge; nitrogen heterocycle; carbocycle; aromatic; alicycle; fused rings; 5ring; 6ring; alcohol; 1fragment
相关文献及参考
- [2]. Kornhuber J, et al. Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One. 2011;6(8)
- [3]. Myhrer T, et al. Antiparkinson drugs used as prophylactics for nerve agents: studies of cognitive side effects in rats. Pharmacol Biochem Behav. 2008 Jun;89(4):633-8.
- Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15
- Short: IV/8A Title: Enthalpies of Fusion and Transition of Organic Compounds Author: Zhang, Z.-Y.; Frenkel, M.; March, K.N.; Wilhoit, R.C. Editor: Marsh, K.N. Source: Landolt-Börnstein, New Series Volume: IV/8A Year: 1995 Keyword: organic compounds; enthaly of fusion; melting point; phase transition ISBN: 3-540-58854-X ISBN: 978-3-540-58854-2 Internet Resource: DOI:10.1007
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 56 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 128,204,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 195 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 128,204,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 750 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,636,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DU
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 340 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,636,1982
其他信息
- MOL 文件:514-65-8.mol
- NIST化学物质信息:Biperiden(514-65-8)
- 毒害物质数据:514-65-8(Hazardous Substances Data)
- 生产方法:以环戊二烯为原料，先与氯乙烯合成氯代双环庚烯，再与镁和乙醚反应，得双环庚烯镁化氯，最后与β-哌啶苯丙酮缩合制得比哌立登。β-哌啶苯丙酮的制备：以苯乙酮为原料与哌啶盐酸盐、甲醛、二甲胺经曼氏反应得到。
- 用途:该品为抗震颤麻痹药、解痉药。小鼠口服LD50为545mg/kg，静脉注射为56mg/kg。
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