4-Hydroxy-2-Methyl-N-(Pyridin-2-Yl)-2H-Benzo[E][1,2]Thiazine-3-Carboxamide 1,1-Dioxide 2-甲基-4-羟基-N-(2-吡啶基)-2H-1,2-苯并异二唑-3-甲酰胺-1,1-二氧化物
CAS 36322-90-4 MFCD00057317
化学结构图
SMILES: CN1C(=C(O)C2C=CC=CC=2S1(=O)=O)C(=O)NC1C=CC=CN=1
化学属性
| Mol. Formula | C15H13N3O4S |
|---|---|
| Mol. Weight | 331.35 |
| TSCA | No |
| Melting Point | 199-203 |
别名和识别编码
| Chemical Name | 4-Hydroxy-2-Methyl-N-(Pyridin-2-Yl)-2H-Benzo[E][1,2]Thiazine-3-Carboxamide 1,1-Dioxide |
|---|---|
| Synonym | CP 16171 4-Hydroxy-2-methyl-3-(pyrid-2-yl-carbamoyl)-2H-1,2-benzothiazine 1,1-dioxide Piroxicamum 4-Hydroxy-2-methyl-3-(pyrid-2-yl-carbamoyl)-2H-1,2-benzothiazine 1,1-dioxide BAXO Piroxicam Piroftal CHF 1251 Feldene 2-甲基-4-羟基-N-(2-吡啶基)-2H-1,2-苯并噻嗪-3-甲酰胺-1,1-二氧化物 4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazin-3-caboxyamid-1,1-dioxid 吡罗昔康 |
| MDL Number | MFCD00057317 |
| PubChem Substance ID | 125307705 |
| EC Number | 252-974-3 |
| CAS Number | 36322-90-4 |
| Merck Number | 7506 |
| Chemical Name Translation | 2-甲基-4-羟基-N-(2-吡啶基)-2H-1,2-苯并异二唑-3-甲酰胺-1,1-二氧化物 |
| Wiswesser Line Notation | T66 BSWNJ C1 EQ DVM- BT6NJ |
| Beilstein Registry Number | 627692 |
| Reaxys-RN | 627692 |
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分类
- {SNA} Core Bioreagents, Enzyme Inhibitors, Pharmacopoeia, Pharmacopoeia A-Z, Research Essentials, 分析/色谱
- {SNA} A to C, Application Index, Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, Cell Signaling Enzymes, Cyclooxygenase, Cyclooxyg
安全信息
GHS Symbol
- P301+P310+P330
- P301+P310
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P405 Store locked up. 上锁保管。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- H301 Toxic if swallowed 吞食有毒
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- R22 Harmful if swallowed 吞咽有害
- R25 Toxic if swallowed 吞咽有毒
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 2400 ug/kg TOXIC EFFECTS : Liver - hepatitis, fibrous (cirrhosis, post-necrotic scarring) Liver - jaundice, other or unclassified Kidney, Ureter, Bladder - other changes in urine composition REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 293,540,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 290 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 49,98,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 335 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 8,4639,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 170 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ATSUDG Archives of Toxicology, Suppleme
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 34 mg/kg SEX/DURATION : female 1-17 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) REFERENCE : TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 30,59,1984
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE : 260 mg/kg SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 8,4655,1980
TYPE OF TEST
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 110 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 8,4655,1980
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