4(3H)-Quinazolinone, 2-methyl-3-o-tolyl-

CAS 72-44-6 MFCD00057320

化学结构图

72-44-6
SMILES: Cc1ccccc1-n1c(C)nc2ccccc2c1=O

化学属性

Mol. FormulaC16H14N2O
Mol. Weight250.32

别名和识别编码

Chemical Name4(3H)-Quinazolinone, 2-methyl-3-o-tolyl-
CAS Number72-44-6
Synonym Noctilene Citexal Melsedin Base Mozambin MTQ 4(3H)-Quinazolinone, 2-methyl-3-(2-methylphenyl)- Somnomed Metolquizolone QZ-2 Mollinox Metaqualon Pro-Dorm NSC 6 RIC 272 Revonal Sopor 2-Methyl-3-o-tolyl-4(3H)-quinazolinone Somberol Lude 2-Methyl-3-o-tolyl-4(3H)-chinazolone Mandrax Fadormir Dorsedin QZ 2 Methaqualone NSC 126877 Methaqualoneinone Cateudyl Omnyl Motolon Hyminal Holodorm 2-Methyl-3-(2-methylphenyl)-4-quinazolinone NSC 111388 Metachalon Quaalude Nethaqualone Normi-nox Parminal Ortonal Roulone 2-Methyl-3-o-tolyl-4(3H)-chinazolinon Dormogen Nobedorm 2-Methyl-3-(2-methyl-phenyl)-4(3H)-quinazolinone Ipnofil Tuazole Orthonal Sindesvel TR-495 2-Methyl-3-tolyl-4-oxybensdiazine Tuazolone Hypcol Dormigoa Mequin 3,4-Dihydro-2-methyl-4-oxo-3-o-tolylquinazoline Dormutil Soverin Rouqualone Hyptor Parest Rorer 148 MAOA 2-Methyl-3-(2-methylphenyl)-4(3H)-quinazolinone Melsomin CI-705 Somnafac 2-Methyl-3-o-tolyl-4-quinazolone 2-Methyl-3-(o-tolyl)-3,4-dihydro-4-quinazolinone 2-Methyl-3-(2-tolyl)quinazol-4-one CN 38703 Hyptor Base Optinoxan Sonal {h
MDL NumberMFCD00057320
Wiswesser Line NotationT66 BVN ENJ CR B1& D1
Beilstein Registry Number0211874
PubChem Substance ID6292
InChIInChI=1S/C16H14N2O/c1-11-7-3-6-10-15(11)18-12(2)17-14-9-5-4-8-13(14)16(18)19/h3-10H,1-2H3
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分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • A quinazoline sedative-hypnotic.

相关文献及参考

  • Brown, S.S., et al.: Clin. Pharmacol. Ther., 14, 314 (1973); Patel, M., et al.: Anal. Profiles Drug Subs., 4, 245 (1975);

安全信息

Restrict {} 精神药品 精麻类化学品
RTECSVA3850000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ATXKA8 Archiv fuer Toxikologie.  (Berlin, Fed. Rep. Ger.)  V.15-31, 1954-74.
    For publisher information, see ARTODN.  Volume(issue)/page/year: 20,31,1963

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 114 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   ATXKA8 Archiv fuer Toxikologie.  (Berlin, Fed. Rep. Ger.)  V.15-31, 1954-74.
    For publisher informatio

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 185 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 24,490,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 57 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
   Gastrointestinal - nausea or vomiting
REFERENCE :
   ATXKA8 Archiv fuer Toxikologie.  (Berlin, Fed. Rep. Ger.)  V.15-31, 1954-74.
    For publisher information, see ARTODN.  Volume(issue)/page/year: 20,31,1963

TYPE OF

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 11 gm/kg
SEX/DURATION            : male 3 day(s) pre-mating
                          female 3 day(s) pre-mating  - 22 day(s) after
                          conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V.1-    1945-  Volume(issue)/page/year: 19,183,1963

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1200 mg/kg
SEX/DURATION            : female 8-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V.1-    1945-  Volume(issue)/page/year: 33,1635,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 900 mg/kg
SEX/DURATION            : female 8-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   10,244,1967

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        :

系列性分类

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