Benzo(6,7)-1,4-diazepino-(5,4-b)-oxazol-6-one,10-chloro-2,3,5,6,7,11b-hexahydro-2-methyl-11b-phenyl-

CAS 24143-17-7 MFCD00058529

化学结构图

24143-17-7
SMILES: CC1CN2CC(=O)NC3C=CC(Cl)=CC=3C2(O1)C1C=CC=CC=1

化学属性

Mol. FormulaC18H17ClN2O2
Mol. Weight328.82

别名和识别编码

Chemical NameBenzo(6,7)-1,4-diazepino-(5,4-b)-oxazol-6-one,10-chloro-2,3,5,6,7,11b-hexahydro-2-methyl-11b-phenyl-
CAS Number24143-17-7
Synonym Oxazolam Serenal Hializan Oxazolazepam Tranquit 10-Chloro-2,3,7,11b-tetrahydro-2-methyl-11b-phenyloxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one
Wiswesser Line NotationT B576 CO FN HVMTT&J BR& D1 MG
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分类

  • Aromatics
  • Heterocycles
  • Neurochemicals
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • A psychotropic agent with anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a precursor to the active substance Desmethyldiazepam (D291595).

相关文献及参考

  • Ochs, H.R. et al.: J. Clin. Pharmacol., 24, 446 (1984); Takagi, H. et al.: Nip. Yakur. Zas., 66, 134 (1970);

安全信息

RTECSDF2800000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85IQAH "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical,
   Medical and Dental Supply Exporters' Assoc., 1972  Volume(issue)/page/year:
   -,91,1972

TYPE OF TEST            : LD50 - Let

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   66,107,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85IQAH "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical,
   Medical and Dental Supply Exporters' Assoc., 1972  Volume(issue)/page/year:
   -,91,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85IQAH "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical,
   Medical and Dental Supply Exporters' Assoc., 1972  Volume(issue)/page/year:
   -,91,1972

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TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 120 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   SKKNAJ Sankyo Kenkyusho Nempo.  Annual Report of Sankyo Research
   Laboratories.  (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku,
   Tokyo 140, Japan)  No.15-    1963-  Volume(issue)/page/year: 21,107,1969

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1800 mg/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   SKKNAJ Sankyo Kenkyusho Nempo.  Annual Report of Sankyo Research
   Laboratories.  (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku,
   Tokyo 140, Japan)  No.15-    1963-  Vol

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 600 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Newborn - live birth index (measured after birth)
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
REFERENCE :
   SKKNAJ Sankyo Kenkyusho Nempo.  Annual Report of Sankyo Research
   Laboratories.  (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku,
   Tokyo 140, Japan)  No.15-    1963-  Volume(issue)/page/year: 21,107,1969

TYPE OF TEST

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