Fenaminosulf 敌磺钠(敌克松)

CAS 140-56-7 MFCD00059900

化学结构图

140-56-7
SMILES: CN(C)c1ccc(/N=N/S(=O)(=O)[O-])cc1.[Na+]

化学属性

Mol. FormulaC8H10N3O3S.Na
Mol. Weight251.26
Solubility不溶于多数有机溶剂，溶于水，易溶于乙醇。

别名和识别编码

Chemical NameDexon
Synonym Sodium p-(dimethylamino)benzenediazosulfonate {Chem Sodium [4-(dimethylamino)phenyl]diazenesulfonate Bayer 22555 Sodium 4-(dimethylamino)benzenediazosulphonate 对二甲氨基苯重氮磺酸钠 敌克松 敌磺酸 4-((Dimethylamino)phenyl)diazenesulfonic acid, sodium salt {Chemi 敌磺钠 Fenaminosulf 对二甲基氨基苯重氮磺酸钠 4-Dimethylaminobenzenediazosulphonic acid, sodium salt p-Dimethylaminobenzenediazosulfonic acid, sodium salt P-DIMETHYLAMINOBENZENEDIAZO-SULFONIC ACID, SODIUM SALT 敌克松原粉 {hazard_c Lesan p-(Dimethylamino)benzenediazosulfonate Deksonal (4-(dimethylamino)phenyl)-diazenesulfonicacisodiumsalt 4-((dimethylamino)phenyl)diazenesulphonicacid,sodiumsalt Diazenesulfonic acid, (4-(dimethylamino)phenyl)-, sodium salt p-Dimethylaminobenzene diazo sodium sulfonate Bayer 5072 Tropaeolin D p-Dimethylaminobenzenediazosodium sulphonate FENAMINOSULF 4-dimethylaminobenzenediazosulfonic*acidsodium p-Diazodimethylaniline sodium sulfonate p-(Dimethylamino)benzenediazosulphonic acid, sodium salt Dexon Diazoben 对二甲胺基苯 4-(dimethylamino)phenyl)diazenesulfonate p-(Dimethylamino)-phenyldiazo-natriumsulfonat 4-(二甲胺基)苯重氮磺酸钠 Sodium p(dimethylamino)benzenediaz DAPA Dexoxon 4-dimet N,N-Dimethyl-p-anilinediazosulfonic acid sodium salt 4-((dimethylamino)phenyl)diazenesulfonicacid,sodiumsalt 对二甲氨基苯重氮基磺酸钠 Sodium (E)-[4-(dimethylamino)phenyl]diazenesulfonate Sodium (4-(dimethylamino)phenyl)dia 地可松
Beilstein Registry Number4170376
PubChem Substance ID23668198
CAS Number140-56-7
EC Number205-419-4
MDL NumberMFCD00059900
Chemical Name Translation敌磺钠(敌克松)
Wiswesser Line NotationWSQNUNR DN1&1 &-NA-
InChIInChI=1S/C8H11N3O3S.Na/c1-11(2)8-5-3-7(4-6-8)9-10-15(12,13)14;/h3-6H,1-2H3,(H,12,13,14);/q;+1/p-1
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分类

  • {Chemicalbook} 农药: 杀菌剂: 化学保护剂
  • {SNA} Azo/Diazo Compounds, Building Blocks, Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks
  • Alpha sort, Alphabetic, Analytical Standards, Analytical/Chromatography, Bactericides, Chromatography, E-G, Environmental Standards, F, FA - FL, Fungicides, Others, Pesticides, Pesticides & Metabolites

相关文献及参考

  • 1. B. Christiansen, et al., Cloning and characterization of a functional human γ-aminobutyric acid (GABA) transporter, human GAT-2 J. Biol. Chem. 282 , 19331-19341, (2007)
  • 2. H. Gonzalez-Diaz, et al., QSAR for anti-RNA-virus activity, synthesis, and assay of anti-RSV carbonucleosides given a unified representation of spectral moments, quadratic, and topologic indices Bioorg. Med. Chem. Lett. 15 , 1651-1657, (2005)
  • 3. D. A. Martens and J. M. Bremner, Inhibitory effects of fungicides on hydrolysis of urea and nitrification of urea nitrogen in soil Pestic. Sci. 49 , 344-352, (1997)

安全信息

Precautionary statements
  • P301+P310
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
WGK Germany3
GHS Symbol
Signal word Danger
Hazard statements
  • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
  • H312 Harmful in contact with skin 皮肤接触有害
  • H301 Toxic if swallowed 吞食有毒
Hazard Codes T
RTECSCZ1750000
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Safety Statements
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Risk Statements
  • R52/53
  • R25 Toxic if swallowed 吞咽有毒
  • R21 Harmful in contact with skin 与皮肤接触有害
Packing GroupIII
Hazard Class6.1(b)
Storage condition -20°C
UN Number UN 2811 6.1/PG 3
Restrict 剧毒化学品 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - m

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Blood - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 95,262,1949

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   WRPCA2 World Review of Pest Control.  (London, UK)  V.1-10, 1962-71.
   Discontinued.  Volume(issue)/page/year: 9,119,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GUCHAZ Guide to the Chemicals Used in Crop Protection.  (Information Canada,
   171 Slater St., Ottawa, Ont., Canada)  Volume(issue)/page/year: 6,274,1973

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AECTCV Archives of Environmental Contamination and Toxico

{hazard_com

TYPE OF TEST            : Mutation in

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 500 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 78,177,1980

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 100 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 52,161,1978

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 1 ug/disc
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 97,339,1982

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 10 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 79,53,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 ug/plate
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United States
   of America.  (National Academy o

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 25 ug/plate
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 13,4923,1985

TYP

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 25 mg/kg
SEX/DURATION            : female 7-11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   CYLPDN Zhongguo Yaoli Xuebao.  Acta Pharmacologica Sinica.  Chinese Journal
   of Pharmacology.  (China International Book Trading Corp., POB 2820,
   Beijing, Peop. Rep. China)  V.1-    1980-  Volume(issue)/page/year:
   4,201,1983

其他信息

  • 用途三:该品为苗田杀菌剂，对腐霉菌素及丝囊霉菌属所引起的病害有特效。对一些真菌性病害也有防效。该品有内吸作用，根部及叶部均能吸收。由植物筛管部及木质部输入其他部位，在植物体内能维特较长时间的药效。可防治水稻期立枯病，黑根病，烂秧病，高梁丝黑穗病，散黑粉病，玉米大斑病，棉花苗期根腐病，炭疽病，立枯病等。
  • 可燃性危险特性:燃烧产生有毒氮氧化物和硫氧化物气体
  • Sigma Aldrich:140-56-7(sigmaaldrich)
  • 毒性分级:高毒
  • 用途一:属苗田杀菌剂，可防治水稻苗期立枯病、高粱丝黑穗病、玉米大斑病、棉花苗期根腐病、炭疽病等
  • 用途二:保护性杀菌剂，有一定的内吸渗透性，主要用于蔬菜、棉花、烟草、水稻等作物的种子处理和土壤处理，兼有一定的治疗作用。防治棉花立枯病、炭疽病用70%可湿性粉剂250～500g，加细土5kg拌和棉籽50kg播种；防治水稻苗期烂秧，用70%可湿性粉剂7.5～15g/100m 2 加水7.5kg；均匀喷洒秧苗；防治白菜软腐病，番茄绵疫病、炭疽病，瓜类枯萎病、炭疽病，用70%可湿性粉剂27.6～55.3g/100m 2 对水喷雾。
  • 外观性质:纯品为淡黄色结晶, 工业品为黄棕色无味粉末。
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • 注意事项:[1]敌磺钠能与碱性农药和农用抗菌素混合使用。 [2]制剂使用时溶解较慢，可先加少量水搅均匀后，再加水稀释溶解，最好现配现用
  • 毒性:大鼠急性经口LD 50 为60～75mg/kg，豚鼠为50mg/kg；大鼠急性经皮LD 50 >100mg/kg。对皮肤有刺激作用。鲫鱼LC 50 2mg/L，鲤鱼LC 50 1.2mg/L。
  • 上游原料:亚硝酸钠 --> 铁粉 --> 亚硫酸钠 --> N,N-二甲基苯胺 --> 4-氨基-N,N-二甲基苯胺 --> 二甲苯胺
  • 方法二:由N，N-二甲基苯胺经亚硝化，还原，重氮化和磺化制得。将二甲基苯胺和稍过量的亚硝酸钠于0-5℃进行亚硝化，加完亚硝酸后用铁粉还原，制成对氨基二甲基苯胺。然后滤去铁粉及生成的四氧化三铁，滤液用亚硝酸钠于0-5℃条件下进行重氮化。加完亚硝酸钠后再用亚硫酸钠进行亚磺化，反应到终点后，敌克松便沉淀出来。得到的敌克松原粉（干品）含量98%。也可以膏状物的形式作为产品，含量55%。生产这一规格的产品，每吨消耗二甲基苯胺310kg。香兰素生产的废水中含有对氨基二甲基苯胺，可用来生产敌克松，而且可以省去亚硝化和还原两道工序。
  • 类别:农药
  • MSDS 信息:对二甲基氨基苯重氮磺酸钠(140-56-7).msds
  • 方法一:由N，N-二甲基苯胺经亚硝化、还原、重氮化和磺化制得。将二甲基苯胺和稍过量亚硝酸于0～5℃进行亚硝化，加完亚硝酸钠后进行还原，制成对氨基二甲苯胺。然后于0～5条件下进行重氮化，加完亚硝酸钠后再用亚硫酸钠进行亚磺化，制得敌磺钠。 因香兰素生产中废水含有对氨基二甲苯胺，用其来生产可省去亚硝化和还原两道工序。香兰素废水先用氨水中和至pH值7～8，加热至40℃左右，沉淀8～12h，除去焦渣。用苯将中和液中的对氨基二甲苯胺萃取出来，萃取液于130～150℃、21.28kPa条件下脱苯，然后在2.66kPa减压蒸馏至130～150℃，得对氨基二甲基苯胺精品。经亚硝酸钠重氮化和亚硫酸钠磺化，制得敌磺钠。
  • 灭火剂:干粉、泡沫、砂土
  • 急救治疗:对症治疗。
  • 中毒症状:刺激眼和皮肤，引起神经系统损害，出现嗜睡、萎靡等症状，严重者可发生抽搐和昏迷。
  • MOL 文件:140-56-7.mol
  • 急性毒性:口服- 大鼠 LD50: 60 毫克 / 公斤

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Azo/Diazo Compounds - Nitrogen Compounds
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Environmental Standards - Chromatography
  5. Pesticides & Metabolites - Environmental Standards
  6. Pesticides - Pesticides & Metabolites
  7. Bactericides - Pesticides
  1. Functional Group 官能团索引
  2. sulfuric acid amide

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